Metastatic cystosarcoma phyllodes: A case report and review of the literature

A. Kessinger, J. F. Foley, H. M. Lemon, D. M. Miller

Research output: Contribution to journalArticle

124 Citations (Scopus)

Abstract

The breast tumor cystosarcoma phyllodes probably does not Rpresent an entity, but rather a spectrum of disease including a benign form, a histologically malignant form, and a metastatic form. In an attempt to better understand the metastatic variant, all 66 cases which could be found in the english literature and an additional case from this institution were reviewed. The tumor often arises from a fibroadenoma, but its etiology is uncertain. Factors that determine the benignity or malignancy of the tumor are unknown, but a lower fertility rate in patients with metastases warrants interest. Incidence is low; cystosarcoma makes up about 0.5% of alI breast tumors and only 3‐12% of these are metastatic. The tumor presents as a breast mass, often of large size, but there is no clinical feature peculiar to the metastatic variant. Gross and microscopic pathologic findings cannot accurately forecast the metastatic potential of the tumor, but are of more predictive value than the clinical presentation. The clinical course is the only sure means of determining metastatic potential at present. Metastases consist of stromal tissue only and can occur in any area of the body. Most commonly the lungs and skeleton are involved. Local recumnce occurs in 51% of metastatic cases. The primary surgical treatment of choice has not yet been defined, but a simple mastectomy with lymph node biopsy seems adequate. Therapy of metastases has been unrewarding thus far.

Original languageEnglish (US)
Pages (from-to)131-147
Number of pages17
JournalJournal of Surgical Oncology
Volume4
Issue number2
DOIs
StatePublished - 1972

Fingerprint

Phyllodes Tumor
Neoplasms
Neoplasm Metastasis
Simple Mastectomy
Breast Neoplasms
Fibroadenoma
Birth Rate
Skeleton
Breast
Lymph Nodes
Biopsy
Lung
Incidence
Therapeutics

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Metastatic cystosarcoma phyllodes : A case report and review of the literature. / Kessinger, A.; Foley, J. F.; Lemon, H. M.; Miller, D. M.

In: Journal of Surgical Oncology, Vol. 4, No. 2, 1972, p. 131-147.

Research output: Contribution to journalArticle

Kessinger, A. ; Foley, J. F. ; Lemon, H. M. ; Miller, D. M. / Metastatic cystosarcoma phyllodes : A case report and review of the literature. In: Journal of Surgical Oncology. 1972 ; Vol. 4, No. 2. pp. 131-147.
@article{221eacdb84b3410eb02d25c2d463bdde,
title = "Metastatic cystosarcoma phyllodes: A case report and review of the literature",
abstract = "The breast tumor cystosarcoma phyllodes probably does not Rpresent an entity, but rather a spectrum of disease including a benign form, a histologically malignant form, and a metastatic form. In an attempt to better understand the metastatic variant, all 66 cases which could be found in the english literature and an additional case from this institution were reviewed. The tumor often arises from a fibroadenoma, but its etiology is uncertain. Factors that determine the benignity or malignancy of the tumor are unknown, but a lower fertility rate in patients with metastases warrants interest. Incidence is low; cystosarcoma makes up about 0.5{\%} of alI breast tumors and only 3‐12{\%} of these are metastatic. The tumor presents as a breast mass, often of large size, but there is no clinical feature peculiar to the metastatic variant. Gross and microscopic pathologic findings cannot accurately forecast the metastatic potential of the tumor, but are of more predictive value than the clinical presentation. The clinical course is the only sure means of determining metastatic potential at present. Metastases consist of stromal tissue only and can occur in any area of the body. Most commonly the lungs and skeleton are involved. Local recumnce occurs in 51{\%} of metastatic cases. The primary surgical treatment of choice has not yet been defined, but a simple mastectomy with lymph node biopsy seems adequate. Therapy of metastases has been unrewarding thus far.",
author = "A. Kessinger and Foley, {J. F.} and Lemon, {H. M.} and Miller, {D. M.}",
year = "1972",
doi = "10.1002/jso.2930040208",
language = "English (US)",
volume = "4",
pages = "131--147",
journal = "Journal of Surgical Oncology",
issn = "0022-4790",
publisher = "Wiley-Liss Inc.",
number = "2",

}

TY - JOUR

T1 - Metastatic cystosarcoma phyllodes

T2 - A case report and review of the literature

AU - Kessinger, A.

AU - Foley, J. F.

AU - Lemon, H. M.

AU - Miller, D. M.

PY - 1972

Y1 - 1972

N2 - The breast tumor cystosarcoma phyllodes probably does not Rpresent an entity, but rather a spectrum of disease including a benign form, a histologically malignant form, and a metastatic form. In an attempt to better understand the metastatic variant, all 66 cases which could be found in the english literature and an additional case from this institution were reviewed. The tumor often arises from a fibroadenoma, but its etiology is uncertain. Factors that determine the benignity or malignancy of the tumor are unknown, but a lower fertility rate in patients with metastases warrants interest. Incidence is low; cystosarcoma makes up about 0.5% of alI breast tumors and only 3‐12% of these are metastatic. The tumor presents as a breast mass, often of large size, but there is no clinical feature peculiar to the metastatic variant. Gross and microscopic pathologic findings cannot accurately forecast the metastatic potential of the tumor, but are of more predictive value than the clinical presentation. The clinical course is the only sure means of determining metastatic potential at present. Metastases consist of stromal tissue only and can occur in any area of the body. Most commonly the lungs and skeleton are involved. Local recumnce occurs in 51% of metastatic cases. The primary surgical treatment of choice has not yet been defined, but a simple mastectomy with lymph node biopsy seems adequate. Therapy of metastases has been unrewarding thus far.

AB - The breast tumor cystosarcoma phyllodes probably does not Rpresent an entity, but rather a spectrum of disease including a benign form, a histologically malignant form, and a metastatic form. In an attempt to better understand the metastatic variant, all 66 cases which could be found in the english literature and an additional case from this institution were reviewed. The tumor often arises from a fibroadenoma, but its etiology is uncertain. Factors that determine the benignity or malignancy of the tumor are unknown, but a lower fertility rate in patients with metastases warrants interest. Incidence is low; cystosarcoma makes up about 0.5% of alI breast tumors and only 3‐12% of these are metastatic. The tumor presents as a breast mass, often of large size, but there is no clinical feature peculiar to the metastatic variant. Gross and microscopic pathologic findings cannot accurately forecast the metastatic potential of the tumor, but are of more predictive value than the clinical presentation. The clinical course is the only sure means of determining metastatic potential at present. Metastases consist of stromal tissue only and can occur in any area of the body. Most commonly the lungs and skeleton are involved. Local recumnce occurs in 51% of metastatic cases. The primary surgical treatment of choice has not yet been defined, but a simple mastectomy with lymph node biopsy seems adequate. Therapy of metastases has been unrewarding thus far.

UR - http://www.scopus.com/inward/record.url?scp=0015259253&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0015259253&partnerID=8YFLogxK

U2 - 10.1002/jso.2930040208

DO - 10.1002/jso.2930040208

M3 - Article

C2 - 4338176

AN - SCOPUS:0015259253

VL - 4

SP - 131

EP - 147

JO - Journal of Surgical Oncology

JF - Journal of Surgical Oncology

SN - 0022-4790

IS - 2

ER -