Metastatic angioinvasive lymphoma (lymphomatoid granulomatosis) in a cat

Douglas G Rogers, Valerie A. Aliano

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A subcutaneous mass removed from the right rear leg of a 17-year-old, spayed, female Domestic Shorthair cat was characterized histopathologically by granulomatous inflammation, sheets of large atypical lymphoid cells, and necrosis. The walls of the small and medium caliber blood vessels were invaded transmurally by atypical lymphoid cells. A diagnosis of angioinvasive lymphoma (AIL), or lymphomatoid granulomatosis, was made based on histopathologic findings. The cat was euthanized 2 months later because of recurrence of the mass and elevated serum alanine aminotransferase activity, and a necropsy was performed. The histopathologic lesion of AIL was seen in the skin and subcutis of the right rear leg, and neoplastic cell infiltrates were seen in adjacent skeletal muscle, right superficial inguinal lymph node, liver, and spleen. By immunohistochemistry, variable numbers of neoplastic cells expressed B-lymphocyte antigen 36 (BLA36) or cluster of differentiation (CD)3 markers, indicative of B- and T-cell lineages, respectively. Neoplastic cells were uniformly positive for vimentin and uniformly negative for cytokeratins and myeloid/histiocytic antigen. Although the cat had received a Rabies virus vaccine subcutaneously in the right rear leg 6 months earlier, the AIL lesion was not typical of vaccine-induced sarcomas. The AIL in this cat was unusual because the extrapulmonary metastases involved the skin and subcutis.

Original languageEnglish (US)
Pages (from-to)390-394
Number of pages5
JournalJournal of Veterinary Diagnostic Investigation
Volume21
Issue number3
DOIs
StatePublished - May 1 2009

Fingerprint

Lymphomatoid Granulomatosis
lymphoma
Lymphoma
Cats
cats
Leg
legs
skin (animal)
lesions (animal)
CD Antigens
B-lymphocytes
Lymphocytes
Rabies Vaccines
Antigens
Rabies virus
Skin
Groin
lymphocyte antigens
vaccines
Vimentin

Keywords

  • Angioinvasive lymphoma
  • Cats
  • Immunohistochemistry
  • Lymphomatoid granulomatosis

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Metastatic angioinvasive lymphoma (lymphomatoid granulomatosis) in a cat. / Rogers, Douglas G; Aliano, Valerie A.

In: Journal of Veterinary Diagnostic Investigation, Vol. 21, No. 3, 01.05.2009, p. 390-394.

Research output: Contribution to journalArticle

Rogers, Douglas G ; Aliano, Valerie A. / Metastatic angioinvasive lymphoma (lymphomatoid granulomatosis) in a cat. In: Journal of Veterinary Diagnostic Investigation. 2009 ; Vol. 21, No. 3. pp. 390-394.
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