Metastasis suppressors and the tumor microenvironment

Leah M. Cook, Douglas R. Hurst, Danny R. Welch

Research output: Contribution to journalReview article

39 Citations (Scopus)

Abstract

The most lethal and debilitating attribute of cancer cells is their ability to metastasize. Throughout the process of metastasis, tumor cells interact with other tumor cells, host cells and a variety of molecules. Tumor cells are also faced with a number of insults, such as hemodynamic sheer pressure and immune selection. This brief review explores how metastasis suppressor proteins regulate interactions between tumor cells and the microenvironments in which tumor cells find themselves.

Original languageEnglish (US)
Pages (from-to)113-122
Number of pages10
JournalSeminars in Cancer Biology
Volume21
Issue number2
DOIs
StatePublished - Apr 1 2011

Fingerprint

Tumor Microenvironment
Neoplasm Metastasis
Neoplasms
Tumor Suppressor Proteins
Cellular Microenvironment
Hemodynamics
Pressure

Keywords

  • Angiogenesis
  • BRMS1
  • CD44
  • Caspase 8
  • DLC1
  • DRG1
  • E-cadherin
  • Gelsolin
  • HUNK
  • JNKK1/MKK7/p38
  • KAI1
  • KISS1
  • Kisspeptin
  • LSD1
  • Nm23
  • OGR1
  • RECK
  • Review
  • RhoGDI2
  • Ribonucleotide reductase M1
  • SseCKS/Gravin/AKAP12
  • TIMP

ASJC Scopus subject areas

  • Cancer Research

Cite this

Metastasis suppressors and the tumor microenvironment. / Cook, Leah M.; Hurst, Douglas R.; Welch, Danny R.

In: Seminars in Cancer Biology, Vol. 21, No. 2, 01.04.2011, p. 113-122.

Research output: Contribution to journalReview article

Cook, Leah M. ; Hurst, Douglas R. ; Welch, Danny R. / Metastasis suppressors and the tumor microenvironment. In: Seminars in Cancer Biology. 2011 ; Vol. 21, No. 2. pp. 113-122.
@article{3d837e4880b54b93933401db632223df,
title = "Metastasis suppressors and the tumor microenvironment",
abstract = "The most lethal and debilitating attribute of cancer cells is their ability to metastasize. Throughout the process of metastasis, tumor cells interact with other tumor cells, host cells and a variety of molecules. Tumor cells are also faced with a number of insults, such as hemodynamic sheer pressure and immune selection. This brief review explores how metastasis suppressor proteins regulate interactions between tumor cells and the microenvironments in which tumor cells find themselves.",
keywords = "Angiogenesis, BRMS1, CD44, Caspase 8, DLC1, DRG1, E-cadherin, Gelsolin, HUNK, JNKK1/MKK7/p38, KAI1, KISS1, Kisspeptin, LSD1, Nm23, OGR1, RECK, Review, RhoGDI2, Ribonucleotide reductase M1, SseCKS/Gravin/AKAP12, TIMP",
author = "Cook, {Leah M.} and Hurst, {Douglas R.} and Welch, {Danny R.}",
year = "2011",
month = "4",
day = "1",
doi = "10.1016/j.semcancer.2010.12.005",
language = "English (US)",
volume = "21",
pages = "113--122",
journal = "Seminars in Cancer Biology",
issn = "1044-579X",
publisher = "Academic Press Inc.",
number = "2",

}

TY - JOUR

T1 - Metastasis suppressors and the tumor microenvironment

AU - Cook, Leah M.

AU - Hurst, Douglas R.

AU - Welch, Danny R.

PY - 2011/4/1

Y1 - 2011/4/1

N2 - The most lethal and debilitating attribute of cancer cells is their ability to metastasize. Throughout the process of metastasis, tumor cells interact with other tumor cells, host cells and a variety of molecules. Tumor cells are also faced with a number of insults, such as hemodynamic sheer pressure and immune selection. This brief review explores how metastasis suppressor proteins regulate interactions between tumor cells and the microenvironments in which tumor cells find themselves.

AB - The most lethal and debilitating attribute of cancer cells is their ability to metastasize. Throughout the process of metastasis, tumor cells interact with other tumor cells, host cells and a variety of molecules. Tumor cells are also faced with a number of insults, such as hemodynamic sheer pressure and immune selection. This brief review explores how metastasis suppressor proteins regulate interactions between tumor cells and the microenvironments in which tumor cells find themselves.

KW - Angiogenesis

KW - BRMS1

KW - CD44

KW - Caspase 8

KW - DLC1

KW - DRG1

KW - E-cadherin

KW - Gelsolin

KW - HUNK

KW - JNKK1/MKK7/p38

KW - KAI1

KW - KISS1

KW - Kisspeptin

KW - LSD1

KW - Nm23

KW - OGR1

KW - RECK

KW - Review

KW - RhoGDI2

KW - Ribonucleotide reductase M1

KW - SseCKS/Gravin/AKAP12

KW - TIMP

UR - http://www.scopus.com/inward/record.url?scp=79952072718&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79952072718&partnerID=8YFLogxK

U2 - 10.1016/j.semcancer.2010.12.005

DO - 10.1016/j.semcancer.2010.12.005

M3 - Review article

C2 - 21168504

AN - SCOPUS:79952072718

VL - 21

SP - 113

EP - 122

JO - Seminars in Cancer Biology

JF - Seminars in Cancer Biology

SN - 1044-579X

IS - 2

ER -