Merkel cell carcinoma

Two case reports focusing on the role of fluorodeoxyglucose positron emission tomography imaging in staging and surveillance

Min Yao, Russell B Smith, Henry T. Hoffman, Gerry F. Funk, Michael M. Graham, John M. Buatti

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Background: Merkel cell carcinoma (MCC) is a rare skin neuroendocrine carcinoma frequently occurring in the head and neck area. It is known for being a locally aggressive disease with a high incidence of regional and distant metastases. Accurate initial staging and close surveillance are critical in the management of the disease. Methods and Results: Two cases of MCC are reported in which fluorine-18-fluorodeoxy glucose positron emission tomography (FDG PET) imaging has been beneficial in directing management and predicting clinical course. Pretreatment FDG PET scans detected metastatic disease in subcentimeter lymph nodes that were not appreciated in initial computed tomography images. Posttreatment FDG PET scans predicted response to therapy with the level of FDG uptake correlating in both areas of complete response to treatment and areas of residual diseases. Finally, FDG PET imaging also detected the progression of the disease after initial treatment. Conclusion: FDG PET imaging is a very sensitive modality in staging, assessment of treatment response, and surveillance of MCC. Because of the rarity of MCC, multicenter study is warranted to accumulate enough cases to determine the sensitivity and specificity of FDG PET in staging and surveillance of MCC, and the impact on the management and treatment outcome.

Original languageEnglish (US)
Pages (from-to)205-210
Number of pages6
JournalAmerican Journal of Clinical Oncology: Cancer Clinical Trials
Volume28
Issue number2
DOIs
StatePublished - Apr 1 2005

Fingerprint

Merkel Cell Carcinoma
Positron-Emission Tomography
Glucose
Neuroendocrine Carcinoma
Fluorine
Disease Management
Multicenter Studies
Disease Progression
Neck
Lymph Nodes
Head
Tomography
Neoplasm Metastasis
Sensitivity and Specificity
Skin
Incidence

Keywords

  • Carcinoma staging
  • Case report
  • FDG PET
  • Human
  • Merkel cell carcinoma
  • Surveillance

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Merkel cell carcinoma : Two case reports focusing on the role of fluorodeoxyglucose positron emission tomography imaging in staging and surveillance. / Yao, Min; Smith, Russell B; Hoffman, Henry T.; Funk, Gerry F.; Graham, Michael M.; Buatti, John M.

In: American Journal of Clinical Oncology: Cancer Clinical Trials, Vol. 28, No. 2, 01.04.2005, p. 205-210.

Research output: Contribution to journalArticle

Yao, Min ; Smith, Russell B ; Hoffman, Henry T. ; Funk, Gerry F. ; Graham, Michael M. ; Buatti, John M. / Merkel cell carcinoma : Two case reports focusing on the role of fluorodeoxyglucose positron emission tomography imaging in staging and surveillance. In: American Journal of Clinical Oncology: Cancer Clinical Trials. 2005 ; Vol. 28, No. 2. pp. 205-210.
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abstract = "Background: Merkel cell carcinoma (MCC) is a rare skin neuroendocrine carcinoma frequently occurring in the head and neck area. It is known for being a locally aggressive disease with a high incidence of regional and distant metastases. Accurate initial staging and close surveillance are critical in the management of the disease. Methods and Results: Two cases of MCC are reported in which fluorine-18-fluorodeoxy glucose positron emission tomography (FDG PET) imaging has been beneficial in directing management and predicting clinical course. Pretreatment FDG PET scans detected metastatic disease in subcentimeter lymph nodes that were not appreciated in initial computed tomography images. Posttreatment FDG PET scans predicted response to therapy with the level of FDG uptake correlating in both areas of complete response to treatment and areas of residual diseases. Finally, FDG PET imaging also detected the progression of the disease after initial treatment. Conclusion: FDG PET imaging is a very sensitive modality in staging, assessment of treatment response, and surveillance of MCC. Because of the rarity of MCC, multicenter study is warranted to accumulate enough cases to determine the sensitivity and specificity of FDG PET in staging and surveillance of MCC, and the impact on the management and treatment outcome.",
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