Melanopsin signaling and nonvisual ocular photoreception

Sowmya V Yelamanchili, Victoria Piamonte, Surendra Kumar Nayak, Nobushige Tanaka, Quansheng Zhu, Kacee Jones, Hiep Le, Satchidananda Panda

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Organisms, ranging from cyanobacteria to mammals, use an intrinsic circadian clock and photosensors to regulate behavior and physiology in resonance with geophysical time. In mammals, an endogenous master clock functions in the suprachiasmatic nuclei (SCN) of the hypothalamus, and is entrained to the day-night cycle by direct light input from the retina. Appropriate photoentrainment is essential for general health, as shift work and similar chronic circadian desynchronization have been shown to be major risk factors in several sleep disorders, metabolic syndromes, and in cancer (reviewed in (1)). Understanding the molecular processes underlying photoentrainment will therefore help identify new strategies and targets for therapeutic intervention in these disorders.

Original languageEnglish (US)
Title of host publicationSignal Transduction in the Retina
PublisherCRC Press
Pages165-192
Number of pages28
ISBN (Electronic)9781420007169
ISBN (Print)9780849373152
StatePublished - Jan 1 2007
Externally publishedYes

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Mammals
Clocks
Circadian Clocks
Suprachiasmatic Nucleus
Physiology
Photoperiod
Cyanobacteria
Hypothalamus
Retina
Health
Neoplasms
melanopsin
Therapeutics
Sleep Wake Disorders
Sleep

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Neuroscience(all)
  • Medicine(all)

Cite this

Yelamanchili, S. V., Piamonte, V., Nayak, S. K., Tanaka, N., Zhu, Q., Jones, K., ... Panda, S. (2007). Melanopsin signaling and nonvisual ocular photoreception. In Signal Transduction in the Retina (pp. 165-192). CRC Press.

Melanopsin signaling and nonvisual ocular photoreception. / Yelamanchili, Sowmya V; Piamonte, Victoria; Nayak, Surendra Kumar; Tanaka, Nobushige; Zhu, Quansheng; Jones, Kacee; Le, Hiep; Panda, Satchidananda.

Signal Transduction in the Retina. CRC Press, 2007. p. 165-192.

Research output: Chapter in Book/Report/Conference proceedingChapter

Yelamanchili, SV, Piamonte, V, Nayak, SK, Tanaka, N, Zhu, Q, Jones, K, Le, H & Panda, S 2007, Melanopsin signaling and nonvisual ocular photoreception. in Signal Transduction in the Retina. CRC Press, pp. 165-192.
Yelamanchili SV, Piamonte V, Nayak SK, Tanaka N, Zhu Q, Jones K et al. Melanopsin signaling and nonvisual ocular photoreception. In Signal Transduction in the Retina. CRC Press. 2007. p. 165-192
Yelamanchili, Sowmya V ; Piamonte, Victoria ; Nayak, Surendra Kumar ; Tanaka, Nobushige ; Zhu, Quansheng ; Jones, Kacee ; Le, Hiep ; Panda, Satchidananda. / Melanopsin signaling and nonvisual ocular photoreception. Signal Transduction in the Retina. CRC Press, 2007. pp. 165-192
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