Melanopsin mediates retrograde visual signaling in the retina

Dao Qi Zhang, Michael A. Belenky, Patricia J. Sollars, Gary E. Pickard, Douglas G. McMahon

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

The canonical flow of visual signals proceeds from outer to inner retina (photoreceptors→bipolar cells→ganglion cells). However, melanopsin-expressing ganglion cells are photosensitive and functional sustained light signaling to retinal dopaminergic interneurons persists in the absence of rods and cones. Here we show that the sustained-type light response of retinal dopamine neurons requires melanopsin and that the response is mediated by AMPA-type glutamate receptors, defining a retrograde retinal visual signaling pathway that fully reverses the usual flow of light signals in retinal circuits.

Original languageEnglish (US)
Article numbere42647
JournalPloS one
Volume7
Issue number8
DOIs
StatePublished - Aug 3 2012

Fingerprint

retina
Retina
Light
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
Glutamate Receptors
Neurons
Retinal Neurons
rods (retina)
Cones
Dopamine
Vertebrate Photoreceptor Cells
Visual Pathways
AMPA Receptors
cones (retina)
Dopaminergic Neurons
interneurons
Interneurons
dopamine
Ganglia
Networks (circuits)

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

Cite this

Melanopsin mediates retrograde visual signaling in the retina. / Zhang, Dao Qi; Belenky, Michael A.; Sollars, Patricia J.; Pickard, Gary E.; McMahon, Douglas G.

In: PloS one, Vol. 7, No. 8, e42647, 03.08.2012.

Research output: Contribution to journalArticle

Zhang, Dao Qi ; Belenky, Michael A. ; Sollars, Patricia J. ; Pickard, Gary E. ; McMahon, Douglas G. / Melanopsin mediates retrograde visual signaling in the retina. In: PloS one. 2012 ; Vol. 7, No. 8.
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