Mef2 promotes spine elimination in absence of δ-catenin

Yang Yuan, Dipika Singh, Jyothi Arikkath

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

δ-Catenin is a component of the cadherin-catenin cell adhesion complex and its loss has been implicated in the mental retardation associated with the Cri du chat syndrome. We have previously demonstrated that loss of δ-catenin in a murine model during development results in excessive spine and synaptic density and function. In order to examine the role of potential molecules that might cooperate with δ-catenin to regulate spine density, we focused on Mef2. Our data demonstrate that while loss of δ-catenin does not alter the expression levels of endogenous Mef2, expression of Mef2 in neurons that are knocked down for δ-catenin promotes spine elimination. These results establish a molecular mechanism by which excessive spines in the absence of δ-catenin may be eliminated and may point toward pharmacological therapy for the Cri du chat syndrome.

Original languageEnglish (US)
Pages (from-to)10-13
Number of pages4
JournalNeuroscience Letters
Volume536
Issue number1
DOIs
Publication statusPublished - Mar 1 2013

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Keywords

  • Mef2
  • Spine
  • Spine elimination
  • δ-Catenin

ASJC Scopus subject areas

  • Neuroscience(all)

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