Meeting report

Regulatory myeloid cells

Drake LaFace, James E Talmadge

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Recent investigations of regulatory myeloid cell mobilization and amplification in response to cancer and chronic inflammation associated with infectious disease and autoimmunity have provided numerous insights into the suppressive mechanisms, pathobiology and potential pharmaceutical modulation of MDSC. Controversies have emerged as hematology investigators, have suggested that regulatory myeloid cells, including MDSC merely reflect normal physiological responses to inflammatory and growth factor stimuli. A recurring theme at the recent "International Immunopharmacology Conference on Regulatory Myeloid cells" held in Arlington, Virginia, October 21-24, 2010, focused on efforts to more clearly elucidate molecular features of MDSC from the immature myeloid cells observed in the circulation in response to acute infection and inflammatory responses. Evidence for the potential contribution of regulatory myeloid cells to pathologic processes and sequelae associated with numerous inflammatory and malignant diseases also suggested that these cells may represent a significant deviation from the normal physiologic responses to acute inflammatory stimuli. The relevance of these research efforts was evident from the discussions by numerous clinical investigations regarding their efforts to modulate MDSC in cancer patients to augment immunotherapeutic treatments.

Original languageEnglish (US)
Pages (from-to)780-782
Number of pages3
JournalInternational Immunopharmacology
Volume11
Issue number7
DOIs
StatePublished - Jul 1 2011

Fingerprint

Myeloid Cells
Hematology
Pathologic Processes
Autoimmunity
Communicable Diseases
Neoplasms
Intercellular Signaling Peptides and Proteins
Research Personnel
Inflammation
Myeloid-Derived Suppressor Cells
Infection
Research
Pharmaceutical Preparations

Keywords

  • MDSC
  • Regulatory Myeloid Cells
  • cancer
  • chemokines
  • cytokines
  • suppression

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Pharmacology

Cite this

Meeting report : Regulatory myeloid cells. / LaFace, Drake; Talmadge, James E.

In: International Immunopharmacology, Vol. 11, No. 7, 01.07.2011, p. 780-782.

Research output: Contribution to journalArticle

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