Mechanisms of in situ activation of peroxidic antimalarials

Research output: Contribution to journalReview article

18 Scopus citations

Abstract

This review describes mechanisms of action of artemisinin-related antimalarials, emphasizing the site and target of activation, pathways of generating reactive species, and possible targets of free radicals with implications for antimalarial peroxide drug design. It also presents a useful link between the mode of action of artemisinin and that of chloroquine, and highlights redox cycles involved in the interaction between the drug and vital biomolecules.

Original languageEnglish (US)
Pages (from-to)284-288
Number of pages5
JournalRedox Report
Volume8
Issue number5
DOIs
StatePublished - Dec 1 2003

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ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Clinical Biochemistry
  • Cell Biology
  • Biochemistry, medical

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