Mechanisms of hormone and growth factor action in the bovine corpus luteum

John S Davis, J. V. May, B. A. Keel

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

The binding of hormones and growth factors to their cell surface receptors leads to an orderly cascade of events leading to activation of cytoplasmic effector molecules. The mechanism of action of luteinizing hormone involves the stimulation of multiple signal transduction effector systems including adenylyl cyclase and inositol phospholipid-specific phospholipasc C (PLC). This results in the formation of second messengers that activate cAMP-dependent, Ca2+-dependent and lipid-dependent protein kinases. Prostagbndin F2a activates PLC which increases intracellular calcium and activates protein kinase C. This results in the activation of a series of protein kinases in the mitogen-activated protein (MAP) kinase cascade, leading to the activation of nuclear transcription factors c-fos and c-jun. Hormone responsive effector systems, therefore, operate by activating families of protein kinases which regulate cell metabolism, secretion, and gene transcription. Growth factors activate specific receptor protein tyrosine kinases which recruit additional signaling molecules (phospholipase Cγ, phosphatidylinositol 3-kinase, She, Grb2, etc.) initiating a cascade of events mediated via MAP kinases. The signaling pathways activated by hormones interact or cross talk with the signaling pathways activated by growth factors. The diversity of cellular signaling mechanisms elicited by hormones and the potential for interactions with signals generated by growth factor receptor tyrosine kinases, may allow fine tuning of cellular responses during the life span of the corpus luteum.

Original languageEnglish (US)
Pages (from-to)1351-1380
Number of pages30
JournalTheriogenology
Volume45
Issue number7
DOIs
StatePublished - Jan 1 1996

Fingerprint

Corpus Luteum
corpus luteum
growth factors
Intercellular Signaling Peptides and Proteins
hormones
protein kinases
Hormones
Protein Kinases
cattle
Mitogen-Activated Protein Kinases
receptor protein-tyrosine kinase
Phosphatidylinositol 3-Kinase
calcium
mitogen-activated protein kinase kinase
cell communication
receptors
adenylate cyclase
Growth Factor Receptors
phospholipase C
second messengers

Keywords

  • Growth factors
  • Hormone action
  • Map kinase
  • Phospholipase C
  • Protein kinases
  • Second messengers

ASJC Scopus subject areas

  • Small Animals
  • Food Animals
  • Animal Science and Zoology
  • Equine

Cite this

Mechanisms of hormone and growth factor action in the bovine corpus luteum. / Davis, John S; May, J. V.; Keel, B. A.

In: Theriogenology, Vol. 45, No. 7, 01.01.1996, p. 1351-1380.

Research output: Contribution to journalArticle

Davis, John S ; May, J. V. ; Keel, B. A. / Mechanisms of hormone and growth factor action in the bovine corpus luteum. In: Theriogenology. 1996 ; Vol. 45, No. 7. pp. 1351-1380.
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