Mechanisms of erythrocyte development and regeneration

Implications for regenerative medicine and beyond

Emery H. Bresnick, Kyle J Hewitt, Charu Mehta, Sunduz Keles, Robert F. Paulson, Kirby D. Johnson

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

Hemoglobin-expressing erythrocytes (red blood cells) act as fundamental metabolic regulators by providing oxygen to cells and tissues throughout the body. Whereas the vital requirement for oxygen to support metabolically active cells and tissues is well established, almost nothing is known regarding how erythrocyte development and function impact regeneration. Furthermore, many questions remain unanswered relating to how insults to hematopoietic stem/progenitor cells and erythrocytes can trigger a massive regenerative process termed ‘stress erythropoiesis’ to produce billions of erythrocytes. Here, we review the cellular and molecular mechanisms governing erythrocyte development and regeneration, and discuss the potential links between these events and other regenerative processes.

Original languageEnglish (US)
Article numberdev151423
JournalDevelopment (Cambridge)
Volume145
Issue number1
DOIs
StatePublished - Jan 1 2018

Fingerprint

Regenerative Medicine
Regeneration
Erythrocytes
Hematopoietic Stem Cells
Oxygen
Erythropoiesis
Hemoglobins

Keywords

  • Erythroblast
  • Erythrocyte
  • Regeneration
  • Stress
  • Transcription

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology

Cite this

Mechanisms of erythrocyte development and regeneration : Implications for regenerative medicine and beyond. / Bresnick, Emery H.; Hewitt, Kyle J; Mehta, Charu; Keles, Sunduz; Paulson, Robert F.; Johnson, Kirby D.

In: Development (Cambridge), Vol. 145, No. 1, dev151423, 01.01.2018.

Research output: Contribution to journalReview article

Bresnick, Emery H. ; Hewitt, Kyle J ; Mehta, Charu ; Keles, Sunduz ; Paulson, Robert F. ; Johnson, Kirby D. / Mechanisms of erythrocyte development and regeneration : Implications for regenerative medicine and beyond. In: Development (Cambridge). 2018 ; Vol. 145, No. 1.
@article{d43dfe0e568244e1acfb9e9d6fbfc81b,
title = "Mechanisms of erythrocyte development and regeneration: Implications for regenerative medicine and beyond",
abstract = "Hemoglobin-expressing erythrocytes (red blood cells) act as fundamental metabolic regulators by providing oxygen to cells and tissues throughout the body. Whereas the vital requirement for oxygen to support metabolically active cells and tissues is well established, almost nothing is known regarding how erythrocyte development and function impact regeneration. Furthermore, many questions remain unanswered relating to how insults to hematopoietic stem/progenitor cells and erythrocytes can trigger a massive regenerative process termed ‘stress erythropoiesis’ to produce billions of erythrocytes. Here, we review the cellular and molecular mechanisms governing erythrocyte development and regeneration, and discuss the potential links between these events and other regenerative processes.",
keywords = "Erythroblast, Erythrocyte, Regeneration, Stress, Transcription",
author = "Bresnick, {Emery H.} and Hewitt, {Kyle J} and Charu Mehta and Sunduz Keles and Paulson, {Robert F.} and Johnson, {Kirby D.}",
year = "2018",
month = "1",
day = "1",
doi = "10.1242/dev.151423",
language = "English (US)",
volume = "145",
journal = "Development (Cambridge)",
issn = "0950-1991",
publisher = "Company of Biologists Ltd",
number = "1",

}

TY - JOUR

T1 - Mechanisms of erythrocyte development and regeneration

T2 - Implications for regenerative medicine and beyond

AU - Bresnick, Emery H.

AU - Hewitt, Kyle J

AU - Mehta, Charu

AU - Keles, Sunduz

AU - Paulson, Robert F.

AU - Johnson, Kirby D.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Hemoglobin-expressing erythrocytes (red blood cells) act as fundamental metabolic regulators by providing oxygen to cells and tissues throughout the body. Whereas the vital requirement for oxygen to support metabolically active cells and tissues is well established, almost nothing is known regarding how erythrocyte development and function impact regeneration. Furthermore, many questions remain unanswered relating to how insults to hematopoietic stem/progenitor cells and erythrocytes can trigger a massive regenerative process termed ‘stress erythropoiesis’ to produce billions of erythrocytes. Here, we review the cellular and molecular mechanisms governing erythrocyte development and regeneration, and discuss the potential links between these events and other regenerative processes.

AB - Hemoglobin-expressing erythrocytes (red blood cells) act as fundamental metabolic regulators by providing oxygen to cells and tissues throughout the body. Whereas the vital requirement for oxygen to support metabolically active cells and tissues is well established, almost nothing is known regarding how erythrocyte development and function impact regeneration. Furthermore, many questions remain unanswered relating to how insults to hematopoietic stem/progenitor cells and erythrocytes can trigger a massive regenerative process termed ‘stress erythropoiesis’ to produce billions of erythrocytes. Here, we review the cellular and molecular mechanisms governing erythrocyte development and regeneration, and discuss the potential links between these events and other regenerative processes.

KW - Erythroblast

KW - Erythrocyte

KW - Regeneration

KW - Stress

KW - Transcription

UR - http://www.scopus.com/inward/record.url?scp=85040797852&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85040797852&partnerID=8YFLogxK

U2 - 10.1242/dev.151423

DO - 10.1242/dev.151423

M3 - Review article

VL - 145

JO - Development (Cambridge)

JF - Development (Cambridge)

SN - 0950-1991

IS - 1

M1 - dev151423

ER -