Mechanism of lymph node metastasis in prostate cancer

Kaustubh Datta, Michael Muders, Heyu Zhang, Donald J. Tindall

Research output: Contribution to journalReview article

40 Scopus citations

Abstract

Detection of lymph node metastases indicates poor prognosis for prostate cancer patients. Therefore, elucidation of the mechanism(s) of lymph node metastasis is important to understand the progression of prostate cancer and also to develop therapeutic interventions. In this article, the known mechanisms for lymph node metastasis are discussed and the involvement of lymphatic vessels in prostate cancer lymph node metastasis is comprehensively summarized. In addition, contradictory findings regarding the importance of lymphangiogenesis in facilitating lymph node metastasis in prostate cancer are pointed out and reconcilation is attempted.

Original languageEnglish (US)
Pages (from-to)823-836
Number of pages14
JournalFuture Oncology
Volume6
Issue number5
DOIs
Publication statusPublished - May 1 2010

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Keywords

  • Lymph node metastasis
  • Lymphangiogenesis
  • Prostate cancer
  • VEGF-C

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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