Mechanical stresses associated with flattening of human femoropopliteal artery specimens during planar biaxial testing and their effects on the calculated physiologic stress–stretch state

Majid Jadidi, Anastasia Desyatova, Jason MacTaggart, Alexey Kamenskiy

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Planar biaxial testing is commonly used to characterize the mechanical properties of arteries, but stresses associated with specimen flattening during this test are unknown. We quantified flattening effects in human femoropopliteal arteries (FPAs) of different ages and determined how they affect the calculated arterial physiologic stress–stretch state. Human FPAs from 472 tissue donors (age 12–82 years, mean 53 ± 16 years) were tested using planar biaxial extension, and morphometric and mechanical characteristics were used to assess the flattening effects. Constitutive parameters for the invariant-based model were adjusted to account for specimen flattening and used to calculate the physiologic stresses, stretches, axial force, circumferential stiffness, and stored energy for the FPAs in seven age groups. Flattened specimens were overall 12 ± 4% stiffer longitudinally and 19 ± 11% stiffer circumferentially when biaxially tested. Differences between the stress–stretch curves adjusted and non-adjusted for the effects of flattening were relatively constant across all age groups longitudinally, but increased with age circumferentially. In all age groups, these differences were smaller than the intersubject variability. Physiologic stresses, stretches, axial force, circumferential stiffness, and stored energy were all qualitatively and quantitatively similar when calculated with and without the flattening effects. Stresses, stretches, axial force, and stored energy reduced with age, but circumferential stiffness remained relatively constant between 25 and 65 years of age suggesting a homeostatic target of 0.75 ± 0.02 MPa. Flattening effects associated with planar biaxial testing are smaller than the intersubject variability and have little influence on the calculated physiologic stress–stretch state of human FPAs.

Original languageEnglish (US)
Pages (from-to)1591-1605
Number of pages15
JournalBiomechanics and Modeling in Mechanobiology
Volume18
Issue number6
DOIs
StatePublished - Dec 1 2019

Fingerprint

Mechanical Stress
Biaxial
Arteries
Testing
Stiffness
Age Groups
Stretch
Energy
Tissue
Mechanical properties
Human
Tissue Donors
Mechanical Properties
Calculate
Unknown
Curve
Target
Invariant

Keywords

  • Aging
  • Constitutive modeling
  • Femoropopliteal artery
  • Physiologic state
  • Planar biaxial test

ASJC Scopus subject areas

  • Biotechnology
  • Modeling and Simulation
  • Mechanical Engineering

Cite this

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title = "Mechanical stresses associated with flattening of human femoropopliteal artery specimens during planar biaxial testing and their effects on the calculated physiologic stress–stretch state",
abstract = "Planar biaxial testing is commonly used to characterize the mechanical properties of arteries, but stresses associated with specimen flattening during this test are unknown. We quantified flattening effects in human femoropopliteal arteries (FPAs) of different ages and determined how they affect the calculated arterial physiologic stress–stretch state. Human FPAs from 472 tissue donors (age 12–82 years, mean 53 ± 16 years) were tested using planar biaxial extension, and morphometric and mechanical characteristics were used to assess the flattening effects. Constitutive parameters for the invariant-based model were adjusted to account for specimen flattening and used to calculate the physiologic stresses, stretches, axial force, circumferential stiffness, and stored energy for the FPAs in seven age groups. Flattened specimens were overall 12 ± 4{\%} stiffer longitudinally and 19 ± 11{\%} stiffer circumferentially when biaxially tested. Differences between the stress–stretch curves adjusted and non-adjusted for the effects of flattening were relatively constant across all age groups longitudinally, but increased with age circumferentially. In all age groups, these differences were smaller than the intersubject variability. Physiologic stresses, stretches, axial force, circumferential stiffness, and stored energy were all qualitatively and quantitatively similar when calculated with and without the flattening effects. Stresses, stretches, axial force, and stored energy reduced with age, but circumferential stiffness remained relatively constant between 25 and 65 years of age suggesting a homeostatic target of 0.75 ± 0.02 MPa. Flattening effects associated with planar biaxial testing are smaller than the intersubject variability and have little influence on the calculated physiologic stress–stretch state of human FPAs.",
keywords = "Aging, Constitutive modeling, Femoropopliteal artery, Physiologic state, Planar biaxial test",
author = "Majid Jadidi and Anastasia Desyatova and Jason MacTaggart and Alexey Kamenskiy",
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T1 - Mechanical stresses associated with flattening of human femoropopliteal artery specimens during planar biaxial testing and their effects on the calculated physiologic stress–stretch state

AU - Jadidi, Majid

AU - Desyatova, Anastasia

AU - MacTaggart, Jason

AU - Kamenskiy, Alexey

PY - 2019/12/1

Y1 - 2019/12/1

N2 - Planar biaxial testing is commonly used to characterize the mechanical properties of arteries, but stresses associated with specimen flattening during this test are unknown. We quantified flattening effects in human femoropopliteal arteries (FPAs) of different ages and determined how they affect the calculated arterial physiologic stress–stretch state. Human FPAs from 472 tissue donors (age 12–82 years, mean 53 ± 16 years) were tested using planar biaxial extension, and morphometric and mechanical characteristics were used to assess the flattening effects. Constitutive parameters for the invariant-based model were adjusted to account for specimen flattening and used to calculate the physiologic stresses, stretches, axial force, circumferential stiffness, and stored energy for the FPAs in seven age groups. Flattened specimens were overall 12 ± 4% stiffer longitudinally and 19 ± 11% stiffer circumferentially when biaxially tested. Differences between the stress–stretch curves adjusted and non-adjusted for the effects of flattening were relatively constant across all age groups longitudinally, but increased with age circumferentially. In all age groups, these differences were smaller than the intersubject variability. Physiologic stresses, stretches, axial force, circumferential stiffness, and stored energy were all qualitatively and quantitatively similar when calculated with and without the flattening effects. Stresses, stretches, axial force, and stored energy reduced with age, but circumferential stiffness remained relatively constant between 25 and 65 years of age suggesting a homeostatic target of 0.75 ± 0.02 MPa. Flattening effects associated with planar biaxial testing are smaller than the intersubject variability and have little influence on the calculated physiologic stress–stretch state of human FPAs.

AB - Planar biaxial testing is commonly used to characterize the mechanical properties of arteries, but stresses associated with specimen flattening during this test are unknown. We quantified flattening effects in human femoropopliteal arteries (FPAs) of different ages and determined how they affect the calculated arterial physiologic stress–stretch state. Human FPAs from 472 tissue donors (age 12–82 years, mean 53 ± 16 years) were tested using planar biaxial extension, and morphometric and mechanical characteristics were used to assess the flattening effects. Constitutive parameters for the invariant-based model were adjusted to account for specimen flattening and used to calculate the physiologic stresses, stretches, axial force, circumferential stiffness, and stored energy for the FPAs in seven age groups. Flattened specimens were overall 12 ± 4% stiffer longitudinally and 19 ± 11% stiffer circumferentially when biaxially tested. Differences between the stress–stretch curves adjusted and non-adjusted for the effects of flattening were relatively constant across all age groups longitudinally, but increased with age circumferentially. In all age groups, these differences were smaller than the intersubject variability. Physiologic stresses, stretches, axial force, circumferential stiffness, and stored energy were all qualitatively and quantitatively similar when calculated with and without the flattening effects. Stresses, stretches, axial force, and stored energy reduced with age, but circumferential stiffness remained relatively constant between 25 and 65 years of age suggesting a homeostatic target of 0.75 ± 0.02 MPa. Flattening effects associated with planar biaxial testing are smaller than the intersubject variability and have little influence on the calculated physiologic stress–stretch state of human FPAs.

KW - Aging

KW - Constitutive modeling

KW - Femoropopliteal artery

KW - Physiologic state

KW - Planar biaxial test

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JO - Biomechanics and Modeling in Mechanobiology

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