Measurement of oxygen saturation in the retina with a spectroscopic sensitive multi aperture camera

Jessica C. Ramella-Roman, Scott A. Mathews, Haryipria Kandimalla, Afshin Nabili, Donald D. Duncan, Salvatore A. D'Anna, Syed Mahmood Shah, Quan Dong Nguyen

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43 Scopus citations

Abstract

We introduce a new multi aperture system capable of capturing six identical images of the human fundus at six different spectral bands. The system is based on a lenslet array architecture and is well suited for spectroscopy application. The multi-aperture system was interfaced with a fundus camera to acquire spectroscopic sensitive images of the retina vessel and ultimately to calculate oxygen saturation in the retina in vivo. In vitro testing showed that the system is able to accurately reconstruct curves of partially oxygenated hemoglobin. In vivo testing on healthy volunteers was conducted and yielded results of oxygen saturation similar to the one reported in the literature, with arterial SO2∼0.95 and venous SO2∼ 0.5.

Original languageEnglish (US)
Pages (from-to)6170-6182
Number of pages13
JournalOptics Express
Volume16
Issue number9
DOIs
StatePublished - Apr 28 2008

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ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

Cite this

Ramella-Roman, J. C., Mathews, S. A., Kandimalla, H., Nabili, A., Duncan, D. D., D'Anna, S. A., Shah, S. M., & Nguyen, Q. D. (2008). Measurement of oxygen saturation in the retina with a spectroscopic sensitive multi aperture camera. Optics Express, 16(9), 6170-6182. https://doi.org/10.1364/OE.16.006170