Measurement of oxygen saturation in the retina with a spectroscopic sensitive multi aperture camera

Jessica C. Ramella-Roman, Scott A. Mathews, Haryipria Kandimalla, Afshin Nabili, Donald D. Duncan, Salvatore A. D'Anna, Syed Mahmood Shah, Quan Dong Nguyen

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

We introduce a new multi aperture system capable of capturing six identical images of the human fundus at six different spectral bands. The system is based on a lenslet array architecture and is well suited for spectroscopy application. The multi-aperture system was interfaced with a fundus camera to acquire spectroscopic sensitive images of the retina vessel and ultimately to calculate oxygen saturation in the retina in vivo. In vitro testing showed that the system is able to accurately reconstruct curves of partially oxygenated hemoglobin. In vivo testing on healthy volunteers was conducted and yielded results of oxygen saturation similar to the one reported in the literature, with arterial SO2∼0.95 and venous SO2∼ 0.5.

Original languageEnglish (US)
Pages (from-to)6170-6182
Number of pages13
JournalOptics Express
Volume16
Issue number9
DOIs
StatePublished - Apr 28 2008

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retina
apertures
cameras
saturation
hemoglobin
oxygen
spectral bands
vessels
curves
spectroscopy

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

Cite this

Ramella-Roman, J. C., Mathews, S. A., Kandimalla, H., Nabili, A., Duncan, D. D., D'Anna, S. A., ... Nguyen, Q. D. (2008). Measurement of oxygen saturation in the retina with a spectroscopic sensitive multi aperture camera. Optics Express, 16(9), 6170-6182. https://doi.org/10.1364/OE.16.006170

Measurement of oxygen saturation in the retina with a spectroscopic sensitive multi aperture camera. / Ramella-Roman, Jessica C.; Mathews, Scott A.; Kandimalla, Haryipria; Nabili, Afshin; Duncan, Donald D.; D'Anna, Salvatore A.; Shah, Syed Mahmood; Nguyen, Quan Dong.

In: Optics Express, Vol. 16, No. 9, 28.04.2008, p. 6170-6182.

Research output: Contribution to journalArticle

Ramella-Roman, JC, Mathews, SA, Kandimalla, H, Nabili, A, Duncan, DD, D'Anna, SA, Shah, SM & Nguyen, QD 2008, 'Measurement of oxygen saturation in the retina with a spectroscopic sensitive multi aperture camera', Optics Express, vol. 16, no. 9, pp. 6170-6182. https://doi.org/10.1364/OE.16.006170
Ramella-Roman JC, Mathews SA, Kandimalla H, Nabili A, Duncan DD, D'Anna SA et al. Measurement of oxygen saturation in the retina with a spectroscopic sensitive multi aperture camera. Optics Express. 2008 Apr 28;16(9):6170-6182. https://doi.org/10.1364/OE.16.006170
Ramella-Roman, Jessica C. ; Mathews, Scott A. ; Kandimalla, Haryipria ; Nabili, Afshin ; Duncan, Donald D. ; D'Anna, Salvatore A. ; Shah, Syed Mahmood ; Nguyen, Quan Dong. / Measurement of oxygen saturation in the retina with a spectroscopic sensitive multi aperture camera. In: Optics Express. 2008 ; Vol. 16, No. 9. pp. 6170-6182.
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