Maturational patterns in right ventricular strain mechanics from the fetus to the young infant

Collin T. Erickson, Philip T. Levy, Mary Craft, Ling Li, David Alan Danford, Shelby Kutty

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Aim: To test the hypothesis that right ventricular (RV) function has age-specific patterns of development, we tracked the evolution of RV strain mechanics by 2D-speckle tracking echocardiography (2DSTE) in healthy subjects from mid-gestation through one year of age. Methods: We conducted a prospective longitudinal echocardiography study in 50 healthy subjects at five time periods across gestation (16–20 weeks, 21–25 weeks, 26–30 weeks, 31–35 weeks, and 36–40 weeks) and four time periods following delivery (1 week, 1 month, 6 months, and 1 year of age). We characterized RV function by measuring RV global and free wall longitudinal strain and systolic strain rate, and segmental longitudinal strain at the apical-, mid-, and basal- ventricular levels of the free wall. Possible associations of gestational age, postnatal age, estimated fetal weight, body surface area, gender, and heart rate on strain were investigated. Results: The magnitudes of RV global and free wall longitudinal strain and global strain rate were decreased throughout gestation (p < 0.05 for all). Following birth, the magnitudes of all measures increased from one week through one year (p < 0.001 for all). RV segmental longitudinal strain maintained a base-to-apex gradient (highest-to-lowest) from mid-gestation through one year (p < 0.001). There was no significant difference in strain patterns based on gender or hear rate. Conclusion: The maturational patterns of RV strain are gestational- and postnatal age- specific. With accepted physiological maturation patterns in healthy subjects, these myocardial deformation parameters can provide a valid basis that allows comparison between health and disease.

Original languageEnglish (US)
Pages (from-to)23-32
Number of pages10
JournalEarly Human Development
Volume129
DOIs
StatePublished - Feb 2019

Fingerprint

Mechanics
Fetus
Right Ventricular Function
Pregnancy
Healthy Volunteers
Gestational Age
Echocardiography
Fetal Weight
Body Surface Area
Longitudinal Studies
Heart Rate
Parturition
Health

Keywords

  • 2D speckle-tracking echocardiography
  • Fetus
  • Myocardial strain
  • Neonates
  • Right ventricle
  • Right ventricular mechanics

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Cite this

Maturational patterns in right ventricular strain mechanics from the fetus to the young infant. / Erickson, Collin T.; Levy, Philip T.; Craft, Mary; Li, Ling; Danford, David Alan; Kutty, Shelby.

In: Early Human Development, Vol. 129, 02.2019, p. 23-32.

Research output: Contribution to journalArticle

@article{1931b5fb7c2e433a8f096a6c657d9173,
title = "Maturational patterns in right ventricular strain mechanics from the fetus to the young infant",
abstract = "Aim: To test the hypothesis that right ventricular (RV) function has age-specific patterns of development, we tracked the evolution of RV strain mechanics by 2D-speckle tracking echocardiography (2DSTE) in healthy subjects from mid-gestation through one year of age. Methods: We conducted a prospective longitudinal echocardiography study in 50 healthy subjects at five time periods across gestation (16–20 weeks, 21–25 weeks, 26–30 weeks, 31–35 weeks, and 36–40 weeks) and four time periods following delivery (1 week, 1 month, 6 months, and 1 year of age). We characterized RV function by measuring RV global and free wall longitudinal strain and systolic strain rate, and segmental longitudinal strain at the apical-, mid-, and basal- ventricular levels of the free wall. Possible associations of gestational age, postnatal age, estimated fetal weight, body surface area, gender, and heart rate on strain were investigated. Results: The magnitudes of RV global and free wall longitudinal strain and global strain rate were decreased throughout gestation (p < 0.05 for all). Following birth, the magnitudes of all measures increased from one week through one year (p < 0.001 for all). RV segmental longitudinal strain maintained a base-to-apex gradient (highest-to-lowest) from mid-gestation through one year (p < 0.001). There was no significant difference in strain patterns based on gender or hear rate. Conclusion: The maturational patterns of RV strain are gestational- and postnatal age- specific. With accepted physiological maturation patterns in healthy subjects, these myocardial deformation parameters can provide a valid basis that allows comparison between health and disease.",
keywords = "2D speckle-tracking echocardiography, Fetus, Myocardial strain, Neonates, Right ventricle, Right ventricular mechanics",
author = "Erickson, {Collin T.} and Levy, {Philip T.} and Mary Craft and Ling Li and Danford, {David Alan} and Shelby Kutty",
year = "2019",
month = "2",
doi = "10.1016/j.earlhumdev.2018.12.015",
language = "English (US)",
volume = "129",
pages = "23--32",
journal = "Early Human Development",
issn = "0378-3782",
publisher = "Elsevier Ireland Ltd",

}

TY - JOUR

T1 - Maturational patterns in right ventricular strain mechanics from the fetus to the young infant

AU - Erickson, Collin T.

AU - Levy, Philip T.

AU - Craft, Mary

AU - Li, Ling

AU - Danford, David Alan

AU - Kutty, Shelby

PY - 2019/2

Y1 - 2019/2

N2 - Aim: To test the hypothesis that right ventricular (RV) function has age-specific patterns of development, we tracked the evolution of RV strain mechanics by 2D-speckle tracking echocardiography (2DSTE) in healthy subjects from mid-gestation through one year of age. Methods: We conducted a prospective longitudinal echocardiography study in 50 healthy subjects at five time periods across gestation (16–20 weeks, 21–25 weeks, 26–30 weeks, 31–35 weeks, and 36–40 weeks) and four time periods following delivery (1 week, 1 month, 6 months, and 1 year of age). We characterized RV function by measuring RV global and free wall longitudinal strain and systolic strain rate, and segmental longitudinal strain at the apical-, mid-, and basal- ventricular levels of the free wall. Possible associations of gestational age, postnatal age, estimated fetal weight, body surface area, gender, and heart rate on strain were investigated. Results: The magnitudes of RV global and free wall longitudinal strain and global strain rate were decreased throughout gestation (p < 0.05 for all). Following birth, the magnitudes of all measures increased from one week through one year (p < 0.001 for all). RV segmental longitudinal strain maintained a base-to-apex gradient (highest-to-lowest) from mid-gestation through one year (p < 0.001). There was no significant difference in strain patterns based on gender or hear rate. Conclusion: The maturational patterns of RV strain are gestational- and postnatal age- specific. With accepted physiological maturation patterns in healthy subjects, these myocardial deformation parameters can provide a valid basis that allows comparison between health and disease.

AB - Aim: To test the hypothesis that right ventricular (RV) function has age-specific patterns of development, we tracked the evolution of RV strain mechanics by 2D-speckle tracking echocardiography (2DSTE) in healthy subjects from mid-gestation through one year of age. Methods: We conducted a prospective longitudinal echocardiography study in 50 healthy subjects at five time periods across gestation (16–20 weeks, 21–25 weeks, 26–30 weeks, 31–35 weeks, and 36–40 weeks) and four time periods following delivery (1 week, 1 month, 6 months, and 1 year of age). We characterized RV function by measuring RV global and free wall longitudinal strain and systolic strain rate, and segmental longitudinal strain at the apical-, mid-, and basal- ventricular levels of the free wall. Possible associations of gestational age, postnatal age, estimated fetal weight, body surface area, gender, and heart rate on strain were investigated. Results: The magnitudes of RV global and free wall longitudinal strain and global strain rate were decreased throughout gestation (p < 0.05 for all). Following birth, the magnitudes of all measures increased from one week through one year (p < 0.001 for all). RV segmental longitudinal strain maintained a base-to-apex gradient (highest-to-lowest) from mid-gestation through one year (p < 0.001). There was no significant difference in strain patterns based on gender or hear rate. Conclusion: The maturational patterns of RV strain are gestational- and postnatal age- specific. With accepted physiological maturation patterns in healthy subjects, these myocardial deformation parameters can provide a valid basis that allows comparison between health and disease.

KW - 2D speckle-tracking echocardiography

KW - Fetus

KW - Myocardial strain

KW - Neonates

KW - Right ventricle

KW - Right ventricular mechanics

UR - http://www.scopus.com/inward/record.url?scp=85059350530&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85059350530&partnerID=8YFLogxK

U2 - 10.1016/j.earlhumdev.2018.12.015

DO - 10.1016/j.earlhumdev.2018.12.015

M3 - Article

C2 - 30616038

AN - SCOPUS:85059350530

VL - 129

SP - 23

EP - 32

JO - Early Human Development

JF - Early Human Development

SN - 0378-3782

ER -