Matrix metalloproteinase-9: Many shades of function in cardiovascular disease

Andriy Yabluchanskiy, Yonggang Ma, Rugmani Padmanabhan Iyer, Michael E. Hall, Merry L. Lindsey

Research output: Contribution to journalReview article

160 Citations (Scopus)

Abstract

Matrix metalloproteinase (MMP)-9, one of the most widely investigated MMPs, regulates pathological remodeling processes that involve inflammation and fibrosis in cardiovascular disease. MMP-9 directly degrades extracellular matrix (ECM) proteins and activates cytokines and chemokines to regulate tissue remodeling. MMP-9 deletion or inhibition has proven overall beneficial in multiple animal models of cardiovascular disease. As such, MMP-9 expression and activity is a common end point measured. MMP-9 cell-specific overexpression, however, has also proven beneficial and highlights the fact that little information is available on the underlying mechanisms of MMP-9 function. In this review, we summarize our current understanding of MMP-9 physiology, including structure, regulation, activation, and downstream effects of increased MMP-9. We discuss MMP-9 roles during inflammation and fibrosis in cardiovascular disease. By concentrating on the substrates of MMP-9 and their roles in cardiovascular disease, we explore the overall function and discuss future directions on the translational potential of MMP-9 based therapies.

Original languageEnglish (US)
Pages (from-to)391-403
Number of pages13
JournalPhysiology
Volume28
Issue number6
DOIs
StatePublished - Nov 1 2013

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Matrix Metalloproteinase 9
Cardiovascular Diseases
Fibrosis
Inflammation
Extracellular Matrix Proteins
Pathologic Processes
Matrix Metalloproteinases
Chemokines
Animal Models
Cytokines

ASJC Scopus subject areas

  • Physiology

Cite this

Matrix metalloproteinase-9 : Many shades of function in cardiovascular disease. / Yabluchanskiy, Andriy; Ma, Yonggang; Iyer, Rugmani Padmanabhan; Hall, Michael E.; Lindsey, Merry L.

In: Physiology, Vol. 28, No. 6, 01.11.2013, p. 391-403.

Research output: Contribution to journalReview article

Yabluchanskiy, Andriy ; Ma, Yonggang ; Iyer, Rugmani Padmanabhan ; Hall, Michael E. ; Lindsey, Merry L. / Matrix metalloproteinase-9 : Many shades of function in cardiovascular disease. In: Physiology. 2013 ; Vol. 28, No. 6. pp. 391-403.
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