Matrix design for matrix-assisted laser desorption ionization: Sensitive determination of PAH-DNA adducts

M. George, J. M Y Wellemans, Ronald Cerny, M. L. Gross, K. Li, Ercole Cavalieri

Research output: Contribution to journalArticle

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Abstract

Two matrices, 4-phenyl-α-eyanocinnamic acid (PCC) and 4-benzyloxy-α-eyanocinnamic acid (BCC), were identified for the determination of polycyclic aromatic hydrocarbon (PAH) adducts of DNA bases by matrix-assisted laser desorption ionization. These matrices were designed based on the concept that the matrix and the analyte should have structural similarities. PCC is a good matrix for the desorption of not only PAH-modified DNA bases, but also PAHs themselves and their metabolites. Detections can be made at the femtomolar level.

Original languageEnglish (US)
Pages (from-to)1021-1025
Number of pages5
JournalJournal of the American Society for Mass Spectrometry
Volume5
Issue number11
DOIs
Publication statusPublished - Nov 1994

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ASJC Scopus subject areas

  • Structural Biology
  • Spectroscopy

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