Matrix design for matrix-assisted laser desorption ionization

Sensitive determination of PAH-DNA adducts

M. George, J. M Y Wellemans, Ronald Cerny, M. L. Gross, K. Li, Ercole Cavalieri

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Two matrices, 4-phenyl-α-eyanocinnamic acid (PCC) and 4-benzyloxy-α-eyanocinnamic acid (BCC), were identified for the determination of polycyclic aromatic hydrocarbon (PAH) adducts of DNA bases by matrix-assisted laser desorption ionization. These matrices were designed based on the concept that the matrix and the analyte should have structural similarities. PCC is a good matrix for the desorption of not only PAH-modified DNA bases, but also PAHs themselves and their metabolites. Detections can be made at the femtomolar level.

Original languageEnglish (US)
Pages (from-to)1021-1025
Number of pages5
JournalJournal of the American Society for Mass Spectrometry
Volume5
Issue number11
DOIs
StatePublished - Jan 1 1994

Fingerprint

Ionization
Desorption
Lasers
Acids
Polycyclic Aromatic Hydrocarbons
Polycyclic aromatic hydrocarbons
Metabolites
DNA
polycyclic aromatic hydrocarbons-DNA adduct

ASJC Scopus subject areas

  • Structural Biology
  • Spectroscopy

Cite this

Matrix design for matrix-assisted laser desorption ionization : Sensitive determination of PAH-DNA adducts. / George, M.; Wellemans, J. M Y; Cerny, Ronald; Gross, M. L.; Li, K.; Cavalieri, Ercole.

In: Journal of the American Society for Mass Spectrometry, Vol. 5, No. 11, 01.01.1994, p. 1021-1025.

Research output: Contribution to journalArticle

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