Maternal deprivation alters expression of neural maturation gene tbr1 in the amygdala paralaminar nucleus in infant female macaques

Danielle M. de Campo, Judy L. Cameron, Joseph M. Miano, David A. Lewis, Karoly Mirnics, Julie L. Fudge

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Early parental loss is associated with social–emotional dysregulation and amygdala physiologic changes. Previously, we examined whole amygdala gene expression in infant monkeys exposed to early maternal deprivation. Here, we focus on an amygdala region with immature neurons at birth: the paralaminar nucleus (PL). We hypothesized that 1) the normal infant PL is enriched in a subset of neural maturation (NM) genes compared to a nearby amygdala subregion; and 2) maternal deprivation would downregulate expression of NM transcripts (mRNA). mRNAs for bcl2, doublecortin, neuroD1, and tbr1—genes expressed in post-mitotic neurons—were enriched in the normal PL. Maternal deprivation at either 1 week or 1 month of age resulted in PL-specific downregulation of tbr1—a transcription factor necessary for directing neuroblasts to a glutamatergic phenotype. tbr1 expression also correlated with typical social behaviors. We conclude that maternal deprivation influences glutamatergic neuronal development in the PL, possibly influencing circuits mediating social learning.

Original languageEnglish (US)
Pages (from-to)235-249
Number of pages15
JournalDevelopmental Psychobiology
Volume59
Issue number2
DOIs
StatePublished - Mar 1 2017

Fingerprint

Maternal Deprivation
Macaca
Amygdala
Genes
Down-Regulation
Messenger RNA
Social Behavior
Haplorhini
Transcription Factors
Basolateral Nuclear Complex
Parturition
Phenotype
Gene Expression
Neurons

Keywords

  • bcl2
  • dcx
  • ganglionic eminence
  • neuroD1
  • social behavior
  • tbr1

ASJC Scopus subject areas

  • Developmental and Educational Psychology
  • Developmental Neuroscience
  • Developmental Biology
  • Behavioral Neuroscience

Cite this

Maternal deprivation alters expression of neural maturation gene tbr1 in the amygdala paralaminar nucleus in infant female macaques. / de Campo, Danielle M.; Cameron, Judy L.; Miano, Joseph M.; Lewis, David A.; Mirnics, Karoly; Fudge, Julie L.

In: Developmental Psychobiology, Vol. 59, No. 2, 01.03.2017, p. 235-249.

Research output: Contribution to journalArticle

de Campo, Danielle M. ; Cameron, Judy L. ; Miano, Joseph M. ; Lewis, David A. ; Mirnics, Karoly ; Fudge, Julie L. / Maternal deprivation alters expression of neural maturation gene tbr1 in the amygdala paralaminar nucleus in infant female macaques. In: Developmental Psychobiology. 2017 ; Vol. 59, No. 2. pp. 235-249.
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