Maternal betamethasone and fetal growth and development in monkey

M. F. Epstein, P. M. Farrell, John W Sparks, G. Pepe, S. G. Driscoll, R. A. Chez

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Betamethasone was administered to pregnant rhesus monkeys of 134 to 150 days' gestation. At operative delivery, umbilical venous plasma cortisol concentrations were significantly lower in the treated group than in the control group, indicating that the agent crossed the placenta. In the treated group, accelerated differentiation was present in several fetal organs including lung, liver, kidney, and adrenal gland. Brain histologic changes suggestive of neuronal injury were found in some instances. There were no differences in the weights of these fetal organs except for liver. It was markedly increased in steroid-treated fetuses and this was accompanied by a fourfold rise in total hepatic glycogen content. These observations suggest that in the subhuman fetal primate, the differentiation of fetal organs in addition to lung is enhanced by short-term corticosteroid treatment while growth is not affected.

Original languageEnglish (US)
Pages (from-to)261-263
Number of pages3
JournalUnknown Journal
Volume127
Issue number3
DOIs
StatePublished - Jan 1 1977

Fingerprint

Betamethasone
Fetal Development
Growth and Development
Haplorhini
Mothers
Umbilicus
Lung
Liver Glycogen
Fetal Weight
Organ Size
Liver
Adrenal Glands
Macaca mulatta
Placenta
Primates
Hydrocortisone
Adrenal Cortex Hormones
Fetus
Steroids
Kidney

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Epstein, M. F., Farrell, P. M., Sparks, J. W., Pepe, G., Driscoll, S. G., & Chez, R. A. (1977). Maternal betamethasone and fetal growth and development in monkey. Unknown Journal, 127(3), 261-263. https://doi.org/10.1016/0002-9378(77)90465-3

Maternal betamethasone and fetal growth and development in monkey. / Epstein, M. F.; Farrell, P. M.; Sparks, John W; Pepe, G.; Driscoll, S. G.; Chez, R. A.

In: Unknown Journal, Vol. 127, No. 3, 01.01.1977, p. 261-263.

Research output: Contribution to journalArticle

Epstein, MF, Farrell, PM, Sparks, JW, Pepe, G, Driscoll, SG & Chez, RA 1977, 'Maternal betamethasone and fetal growth and development in monkey', Unknown Journal, vol. 127, no. 3, pp. 261-263. https://doi.org/10.1016/0002-9378(77)90465-3
Epstein, M. F. ; Farrell, P. M. ; Sparks, John W ; Pepe, G. ; Driscoll, S. G. ; Chez, R. A. / Maternal betamethasone and fetal growth and development in monkey. In: Unknown Journal. 1977 ; Vol. 127, No. 3. pp. 261-263.
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