Massive occlusive thrombosis of the pulmonary artery in pigtailed macaques chronically infected with R5-tropic simian-human immunodeficiency virus

Cynthia L. Courtney, Kelly F. Ethun, Francois Villinger, Ruth M. Ruprecht, Siddappa N. Byrareddy

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Pulmonary arterial hypertension (PAH) has been identified as a serious complication of HIV infection. Methods and Results: Here, we report sudden death in two pigtailed macaques (Macaca nemestrina) chronically infected (~1-2 years post-infection) with an R5 SHIV strain. At necropsy, total occlusion of the pulmonary artery by a large fibrin thrombus was present in both animals. Conclusion: This report describes pulmonary vascular lesions similar to PAH in R5 SHIV-infected pigtail macaques.

Original languageEnglish (US)
Pages (from-to)35-39
Number of pages5
JournalJournal of medical primatology
Volume44
Issue number1
DOIs
StatePublished - Feb 1 2015

Fingerprint

Macaca nemestrina
Simian Immunodeficiency Virus
pulmonary artery
thrombosis
Human immunodeficiency virus
Macaca
Pulmonary Hypertension
Pulmonary Artery
tropics
Thrombosis
lungs
HIV
hypertension
Sudden Death
Fibrin
HIV Infections
Blood Vessels
fibrin
HIV infections
blood vessels

Keywords

  • Pulmonary arterial hypertension
  • SHIV
  • SIV

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

Cite this

Massive occlusive thrombosis of the pulmonary artery in pigtailed macaques chronically infected with R5-tropic simian-human immunodeficiency virus. / Courtney, Cynthia L.; Ethun, Kelly F.; Villinger, Francois; Ruprecht, Ruth M.; Byrareddy, Siddappa N.

In: Journal of medical primatology, Vol. 44, No. 1, 01.02.2015, p. 35-39.

Research output: Contribution to journalArticle

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