Marital status and survival in pancreatic cancer patients

A SEER based analysis

Michael Baine, Freshta Sahak, Chi Lin, Subhankar Chakraborty, Elizabeth Lyden, Surinder Kumar Batra

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Background: Recent findings suggest that marital status affects survival in patients with different types of cancer. However, its role in the survival of patients with pancreatic ductal adenocarcinoma is unknown. In this study, we investigated whether there was an association between marital status and overall survival (OS) in patients with pancreatic ductal adenocarcinoma (PDAC). Methods: Adult patients diagnosed with PDAC between 1998 and 2003 with known marital statuses were identified from the Surveillance, Epidemiology, and End Results registry of the National Cancer Institute. OS for these patients was plotted using the Kaplan-Meier method. Comparative risks of mortality were evaluated by using univariate and multivariate-adjusted Cox regression models. Results: Using Kaplan-Meier analysis, we found that the median overall survival of patients was 4 months and 3 months (p<0.001) for married and unmarried patients, respectively. Subgroup analysis on patients with cancer-directed surgery showed that the median survival was 16 months and 13 months (P<0.0005) for married and unmarried groups, respectively. Multivariate analysis adjusting for age, race, sex, stage, year of diagnosis, radiation therapy and cancer-directed surgery showed that patients who were married at the time of diagnosis had a significantly decreased risk of death at both 2 months (15% risk reduction) and 3 years (13% risk reduction) post diagnosis. Conclusions: Marital status is an independent prognostic factor of both perioperative and long-term survival in patients with PDAC. This observation may suggest a suboptimally met psychosocial need among PDAC patients that is partially fulfilled by the support system provided by marriage.

Original languageEnglish (US)
Article numbere21052
JournalPloS one
Volume6
Issue number6
DOIs
StatePublished - Jun 20 2011

Fingerprint

marital status
pancreatic neoplasms
Marital Status
Pancreatic Neoplasms
Survival
Surgery
adenocarcinoma
Adenocarcinoma
Epidemiology
risk reduction
Radiotherapy
neoplasms
Risk Reduction Behavior
Association reactions
surgery
Neoplasms
marriage
support systems
National Cancer Institute (U.S.)
Kaplan-Meier Estimate

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Marital status and survival in pancreatic cancer patients : A SEER based analysis. / Baine, Michael; Sahak, Freshta; Lin, Chi; Chakraborty, Subhankar; Lyden, Elizabeth; Batra, Surinder Kumar.

In: PloS one, Vol. 6, No. 6, e21052, 20.06.2011.

Research output: Contribution to journalArticle

Baine, Michael ; Sahak, Freshta ; Lin, Chi ; Chakraborty, Subhankar ; Lyden, Elizabeth ; Batra, Surinder Kumar. / Marital status and survival in pancreatic cancer patients : A SEER based analysis. In: PloS one. 2011 ; Vol. 6, No. 6.
@article{b4feb3e84095435584a37aa7c3024125,
title = "Marital status and survival in pancreatic cancer patients: A SEER based analysis",
abstract = "Background: Recent findings suggest that marital status affects survival in patients with different types of cancer. However, its role in the survival of patients with pancreatic ductal adenocarcinoma is unknown. In this study, we investigated whether there was an association between marital status and overall survival (OS) in patients with pancreatic ductal adenocarcinoma (PDAC). Methods: Adult patients diagnosed with PDAC between 1998 and 2003 with known marital statuses were identified from the Surveillance, Epidemiology, and End Results registry of the National Cancer Institute. OS for these patients was plotted using the Kaplan-Meier method. Comparative risks of mortality were evaluated by using univariate and multivariate-adjusted Cox regression models. Results: Using Kaplan-Meier analysis, we found that the median overall survival of patients was 4 months and 3 months (p<0.001) for married and unmarried patients, respectively. Subgroup analysis on patients with cancer-directed surgery showed that the median survival was 16 months and 13 months (P<0.0005) for married and unmarried groups, respectively. Multivariate analysis adjusting for age, race, sex, stage, year of diagnosis, radiation therapy and cancer-directed surgery showed that patients who were married at the time of diagnosis had a significantly decreased risk of death at both 2 months (15{\%} risk reduction) and 3 years (13{\%} risk reduction) post diagnosis. Conclusions: Marital status is an independent prognostic factor of both perioperative and long-term survival in patients with PDAC. This observation may suggest a suboptimally met psychosocial need among PDAC patients that is partially fulfilled by the support system provided by marriage.",
author = "Michael Baine and Freshta Sahak and Chi Lin and Subhankar Chakraborty and Elizabeth Lyden and Batra, {Surinder Kumar}",
year = "2011",
month = "6",
day = "20",
doi = "10.1371/journal.pone.0021052",
language = "English (US)",
volume = "6",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "6",

}

TY - JOUR

T1 - Marital status and survival in pancreatic cancer patients

T2 - A SEER based analysis

AU - Baine, Michael

AU - Sahak, Freshta

AU - Lin, Chi

AU - Chakraborty, Subhankar

AU - Lyden, Elizabeth

AU - Batra, Surinder Kumar

PY - 2011/6/20

Y1 - 2011/6/20

N2 - Background: Recent findings suggest that marital status affects survival in patients with different types of cancer. However, its role in the survival of patients with pancreatic ductal adenocarcinoma is unknown. In this study, we investigated whether there was an association between marital status and overall survival (OS) in patients with pancreatic ductal adenocarcinoma (PDAC). Methods: Adult patients diagnosed with PDAC between 1998 and 2003 with known marital statuses were identified from the Surveillance, Epidemiology, and End Results registry of the National Cancer Institute. OS for these patients was plotted using the Kaplan-Meier method. Comparative risks of mortality were evaluated by using univariate and multivariate-adjusted Cox regression models. Results: Using Kaplan-Meier analysis, we found that the median overall survival of patients was 4 months and 3 months (p<0.001) for married and unmarried patients, respectively. Subgroup analysis on patients with cancer-directed surgery showed that the median survival was 16 months and 13 months (P<0.0005) for married and unmarried groups, respectively. Multivariate analysis adjusting for age, race, sex, stage, year of diagnosis, radiation therapy and cancer-directed surgery showed that patients who were married at the time of diagnosis had a significantly decreased risk of death at both 2 months (15% risk reduction) and 3 years (13% risk reduction) post diagnosis. Conclusions: Marital status is an independent prognostic factor of both perioperative and long-term survival in patients with PDAC. This observation may suggest a suboptimally met psychosocial need among PDAC patients that is partially fulfilled by the support system provided by marriage.

AB - Background: Recent findings suggest that marital status affects survival in patients with different types of cancer. However, its role in the survival of patients with pancreatic ductal adenocarcinoma is unknown. In this study, we investigated whether there was an association between marital status and overall survival (OS) in patients with pancreatic ductal adenocarcinoma (PDAC). Methods: Adult patients diagnosed with PDAC between 1998 and 2003 with known marital statuses were identified from the Surveillance, Epidemiology, and End Results registry of the National Cancer Institute. OS for these patients was plotted using the Kaplan-Meier method. Comparative risks of mortality were evaluated by using univariate and multivariate-adjusted Cox regression models. Results: Using Kaplan-Meier analysis, we found that the median overall survival of patients was 4 months and 3 months (p<0.001) for married and unmarried patients, respectively. Subgroup analysis on patients with cancer-directed surgery showed that the median survival was 16 months and 13 months (P<0.0005) for married and unmarried groups, respectively. Multivariate analysis adjusting for age, race, sex, stage, year of diagnosis, radiation therapy and cancer-directed surgery showed that patients who were married at the time of diagnosis had a significantly decreased risk of death at both 2 months (15% risk reduction) and 3 years (13% risk reduction) post diagnosis. Conclusions: Marital status is an independent prognostic factor of both perioperative and long-term survival in patients with PDAC. This observation may suggest a suboptimally met psychosocial need among PDAC patients that is partially fulfilled by the support system provided by marriage.

UR - http://www.scopus.com/inward/record.url?scp=79958774004&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79958774004&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0021052

DO - 10.1371/journal.pone.0021052

M3 - Article

VL - 6

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 6

M1 - e21052

ER -