Marinopyrroles: Unique Drug Discoveries Based on Marine Natural Products

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13 Scopus citations

Abstract

Natural products provide a successful supply of new chemical entities (NCEs) for drug discovery to treat human diseases. Approximately half of the NCEs are based on natural products and their derivatives. Notably, marine natural products, a largely untapped resource, have contributed to drug discovery and development with eight drugs or cosmeceuticals approved by the U.S. Food and Drug Administration and European Medicines Agency, and ten candidates undergoing clinical trials. Collaborative efforts from drug developers, biologists, organic, medicinal, and natural product chemists have elevated drug discoveries to new levels. These efforts are expected to continue to improve the efficiency of natural product-based drugs. Marinopyrroles are examined here as a case study for potential anticancer and antibiotic agents.

Original languageEnglish (US)
Pages (from-to)169-189
Number of pages21
JournalMedicinal Research Reviews
Volume36
Issue number1
DOIs
StatePublished - Jan 1 2016

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Keywords

  • Antibiotics
  • Anticancer
  • Drug discovery
  • Marine natural products
  • Marinopyrroles
  • Staphylococcus aureus

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery

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