Marinopyrrole derivatives as potential antibiotic agents against methicillin-resistant Staphylococcus aureus (I)

Yan Liu, Nina M. Haste, Wdee Thienphrapa, Victor Nizet, Mary Hensler, Rongshi Li

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Infections caused by drug-resistant pathogens are on the rise. The ongoing spread of methicillin-resistant Staphylococcus aureus (MRSA) strains exemplifies the urgent need for new antibiotics. The marine natural product, marinopyrrole A, was previously shown to have potent antibiotic activity against Gram-positive pathogens, including MRSA. However, its minimum inhibitory concentration (MIC) against MRSA was increased by >500 fold in the presence of 20% human serum, thus greatly limiting therapeutic potential. Here we report our discovery of a novel derivative of marinopyrrole A, designated 1a, featuring a 2-4 fold improved MIC against MRSA and significantly less susceptibility to serum inhibition. Importantly, compound 1a displayed rapid and concentration-dependent killing of MRSA. Compared to the natural product counterpart, compound 1a provides an important natural product based scaffold for further Structure Activity Relationship (SAR) and optimization.

Original languageEnglish (US)
Pages (from-to)953-962
Number of pages10
JournalMarine Drugs
Volume10
Issue number4
DOIs
StatePublished - Apr 1 2012

Fingerprint

Methicillin-Resistant Staphylococcus aureus
Anti-Bacterial Agents
Biological Products
Microbial Sensitivity Tests
Structure-Activity Relationship
Serum
Infection
Pharmaceutical Preparations
marinopyrrole A
Therapeutics

Keywords

  • Antibiotics
  • Asymmetrical marinopyrroles
  • MRSA
  • Marinopyrrole
  • SAR

ASJC Scopus subject areas

  • Drug Discovery

Cite this

Marinopyrrole derivatives as potential antibiotic agents against methicillin-resistant Staphylococcus aureus (I). / Liu, Yan; Haste, Nina M.; Thienphrapa, Wdee; Nizet, Victor; Hensler, Mary; Li, Rongshi.

In: Marine Drugs, Vol. 10, No. 4, 01.04.2012, p. 953-962.

Research output: Contribution to journalArticle

Liu, Yan ; Haste, Nina M. ; Thienphrapa, Wdee ; Nizet, Victor ; Hensler, Mary ; Li, Rongshi. / Marinopyrrole derivatives as potential antibiotic agents against methicillin-resistant Staphylococcus aureus (I). In: Marine Drugs. 2012 ; Vol. 10, No. 4. pp. 953-962.
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