Abstract

Agriculture industry workers are at a higher risk for chronic bronchitis and obstructive pulmonary diseases, and current therapeutics are not entirely effective. We previously found that the specialized proresolving lipid mediator maresin-1 (MaR1) reduced proinflammatory cytokine release and intracellular adhesion molecule-1 (ICAM-1) expression in bronchial epithelial cells exposed to extracts of organic dust (DE) derived from swine confinement facilities in vitro. The objective of this study was to determine whether MaR1 is effective at limiting lung inflammation associated with acute and repetitive exposures to DE in an established murine model of inhalant dust exposures. C57Bl/6 mice were treated with MaR1 or vehicle control and intranasally instilled with DE once or daily for 3 weeks. Bronchioalveolar lavage fluid was analyzed for total and differential cell counts and proinflammatory cytokine levels, and lung tissues were assessed for histopathology and ICAM-1 expression. In both single and repetitive DE exposure studies, MaR1 significantly decreased bronchoalveolar lavage neutrophil infiltration, interleukin 6, tumor necrosis factor α, and chemokine C-X-C motif ligand 1 levels without altering repetitive DE-induced bronchioalveolar inflammation or lymphoid aggregate formation. Lung tissue ICAM-1 expression was also reduced in both single and repetitive exposure studies. These data suggest that MaR1 might contribute to an effective strategy to reduce airway inflammatory diseases induced by agricultural-related organic dust environmental exposures.

Original languageEnglish (US)
Pages (from-to)57-69
Number of pages13
JournalTranslational Research
Volume166
Issue number1
DOIs
StatePublished - Jul 1 2015

Fingerprint

Dust
Inflammation
Adhesion
Bronchoalveolar Lavage
Molecules
Chemokine CXCL1
Lymphotoxin-beta
Tissue Adhesions
Tissue
Cytokines
Lung
Pulmonary diseases
Neutrophil Infiltration
Chronic Bronchitis
Environmental Exposure
Agriculture
Infiltration
Chronic Obstructive Pulmonary Disease
Interleukin-6
Pneumonia

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, medical
  • Public Health, Environmental and Occupational Health

Cite this

Maresin-1 reduces airway inflammation associated with acute and repetitive exposures to organic dust. / Nordgren, Tara M.; Bauer, Christopher D.; Heires, Art J.; Poole, Jill A; Wyatt, Todd A; West, William W.; Romberger, Debra.

In: Translational Research, Vol. 166, No. 1, 01.07.2015, p. 57-69.

Research output: Contribution to journalArticle

Nordgren, Tara M. ; Bauer, Christopher D. ; Heires, Art J. ; Poole, Jill A ; Wyatt, Todd A ; West, William W. ; Romberger, Debra. / Maresin-1 reduces airway inflammation associated with acute and repetitive exposures to organic dust. In: Translational Research. 2015 ; Vol. 166, No. 1. pp. 57-69.
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