Mantle cell lymphoma with plasma cell differentiation

Ken H. Young, Wing C. Chan, Kai Fu, Javeed Iqbal, Warren G. Sanger, Anne Ratashak, Timothy Charles Greiner, Dennis D. Weisenburger

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The differentiation of B lymphocytes into plasma cells (PCs) is an antigen-mediated process that largely depends on the interaction between B cells and regulatory factors in their microenvironment. Long-lived PCs are derived from activated B cells in the germinal center (GC), whereas PC differentiation from naive B cells occurs in the extrafollicular areas and the PCs are short-lived. Consequently, lymphomas arising from post-GC B cells often exhibit plasmacytic differentiation, whereas lymphomas arising from naive B cells less commonly show plasmacytic differentiation. Herein, we report 2 cases of mantle cell lymphoma (MCL) with clonal PC differentiation. Both cases presented with the typical cytologic features of MCL and were characterized by a nodular and mantle-zone growth pattern. Clusters of clonal PCs with monotypic κ light chain expression were identified in the centers of the tumor nodules and within reactive GCs. FICTION (Fluorescence immunophenotyping and Interphase Cytogenetics as a Tool for the Investigation Of Neoplasms) analysis demonstrated the characteristic t(11;14)(q13;q32) in both the MCL cells and clonal PCs, indicating that both cell types were derived from the same B-cell clone. These findings indicate that the clonal PC differentiation may occur within GCs in some cases of MCL.

Original languageEnglish (US)
Pages (from-to)954-961
Number of pages8
JournalAmerican Journal of Surgical Pathology
Volume30
Issue number8
DOIs
StatePublished - Aug 1 2006

Fingerprint

Mantle-Cell Lymphoma
Plasma Cells
Cell Differentiation
B-Lymphocytes
Germinal Center
Lymphoma
Regulatory B-Lymphocytes
Immunophenotyping
Interphase
Cytogenetics
Neoplasms
Clone Cells
Fluorescence
Light
Antigens

Keywords

  • FICTION
  • Germinal center
  • Mantle cell lymphoma
  • Plasma cell differentiation

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine

Cite this

Young, K. H., Chan, W. C., Fu, K., Iqbal, J., Sanger, W. G., Ratashak, A., ... Weisenburger, D. D. (2006). Mantle cell lymphoma with plasma cell differentiation. American Journal of Surgical Pathology, 30(8), 954-961. https://doi.org/10.1097/00000478-200608000-00004

Mantle cell lymphoma with plasma cell differentiation. / Young, Ken H.; Chan, Wing C.; Fu, Kai; Iqbal, Javeed; Sanger, Warren G.; Ratashak, Anne; Greiner, Timothy Charles; Weisenburger, Dennis D.

In: American Journal of Surgical Pathology, Vol. 30, No. 8, 01.08.2006, p. 954-961.

Research output: Contribution to journalArticle

Young, Ken H. ; Chan, Wing C. ; Fu, Kai ; Iqbal, Javeed ; Sanger, Warren G. ; Ratashak, Anne ; Greiner, Timothy Charles ; Weisenburger, Dennis D. / Mantle cell lymphoma with plasma cell differentiation. In: American Journal of Surgical Pathology. 2006 ; Vol. 30, No. 8. pp. 954-961.
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