Management of immune cytopenias in patients with systemic lupus erythematosus - Old and new

Kam Newman, Mohammad Bagher Owlia, Ihab El-Hemaidi, Mojtaba Akhtari

Research output: Contribution to journalReview article

34 Citations (Scopus)

Abstract

There are various immune cytopenias associated with systemic lupus erythematosus (SLE). The most common one is anemia; however, there are different etiologies for the anemia caused by SLE. Anemia could be due to chronic disease, secondary to renal insufficiency, blood loss, drug induced or autoimmune hemolysis. There are other very rare causes of anemia secondary to SLE which include red cell aplasia, aplastic anemia, and microangiopathic hemolytic anemia. Treatment of the anemia would be according to the cause. Leukopenia, neutropenia, and lymphopenia are hematologic complications associated with SLE, and in majority of cases no treatment is required. Thrombocytopenia is one of the complications of SLE and is usually treated by steroids. However, there are significant numbers of patients which will either not respond to or relapse after treatment. This article summarizes immune cytopenias seen in patients with SLE, and it also discusses management of these cytopenias.

Original languageEnglish (US)
Pages (from-to)784-791
Number of pages8
JournalAutoimmunity Reviews
Volume12
Issue number7
DOIs
StatePublished - May 1 2013

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Systemic Lupus Erythematosus
Anemia
Lymphopenia
Aplastic Anemia
Hemolytic Anemia
Leukopenia
Hemolysis
Neutropenia
Thrombocytopenia
Renal Insufficiency
Chronic Disease
Therapeutics
Steroids
Recurrence
Pharmaceutical Preparations

Keywords

  • Cytopenia
  • G-CSF
  • Growth factors
  • Hematologic manifestation
  • SLE
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Management of immune cytopenias in patients with systemic lupus erythematosus - Old and new. / Newman, Kam; Owlia, Mohammad Bagher; El-Hemaidi, Ihab; Akhtari, Mojtaba.

In: Autoimmunity Reviews, Vol. 12, No. 7, 01.05.2013, p. 784-791.

Research output: Contribution to journalReview article

Newman, Kam ; Owlia, Mohammad Bagher ; El-Hemaidi, Ihab ; Akhtari, Mojtaba. / Management of immune cytopenias in patients with systemic lupus erythematosus - Old and new. In: Autoimmunity Reviews. 2013 ; Vol. 12, No. 7. pp. 784-791.
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