Management of immune cytopenias in patients with systemic lupus erythematosus - Old and new

Kam Newman, Mohammad Bagher Owlia, Ihab El-Hemaidi, Mojtaba Akhtari

Research output: Contribution to journalReview article

36 Scopus citations

Abstract

There are various immune cytopenias associated with systemic lupus erythematosus (SLE). The most common one is anemia; however, there are different etiologies for the anemia caused by SLE. Anemia could be due to chronic disease, secondary to renal insufficiency, blood loss, drug induced or autoimmune hemolysis. There are other very rare causes of anemia secondary to SLE which include red cell aplasia, aplastic anemia, and microangiopathic hemolytic anemia. Treatment of the anemia would be according to the cause. Leukopenia, neutropenia, and lymphopenia are hematologic complications associated with SLE, and in majority of cases no treatment is required. Thrombocytopenia is one of the complications of SLE and is usually treated by steroids. However, there are significant numbers of patients which will either not respond to or relapse after treatment. This article summarizes immune cytopenias seen in patients with SLE, and it also discusses management of these cytopenias.

Original languageEnglish (US)
Pages (from-to)784-791
Number of pages8
JournalAutoimmunity Reviews
Volume12
Issue number7
DOIs
StatePublished - May 1 2013

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Keywords

  • Cytopenia
  • G-CSF
  • Growth factors
  • Hematologic manifestation
  • SLE
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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