Management guidelines for laboratory exposures to agents of bioterrorism

Janice M. Rusnak, Mark G. Kortepeter, Robert J. Hawley, Ellen Boudreau, John Aldis, Phillip R. Pittman

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Over the past several years, funding for biodefense research has increased dramatically, leading to the possibility of increased laboratory-acquired infections with potential bioterrorism agents. The Special Immunizations Program at United States Army Medical Research Institute of Infectious Diseases reviewed its policy and management of potential occupational exposures (1989-2002) to assess guidelines for determining the risk of exposure and disease and to determine criteria for initiating postexposure prophylaxis (PEP). Initiating antibiotic PEP was based primarily on exposure risk but was also influenced by vaccination status and agent virulence. PEP was given to nearly all moderate- and high-risk bacterial exposures, regardless of vaccination status, to most unvaccinated and subsets of vaccinated minimal-risk exposures, but generally not to negligible-risk exposures. Algorithms for evaluating and managing potential exposures are presented to provide guidance to other agencies as they begin to work with these agents.

Original languageEnglish (US)
Pages (from-to)791-800
Number of pages10
JournalJournal of occupational and environmental medicine
Volume46
Issue number8
DOIs
StatePublished - Aug 1 2004

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Biological Warfare Agents
Guidelines
Vaccination
Laboratory Infection
Immunization Programs
Antibiotic Prophylaxis
Occupational Exposure
Communicable Diseases
Virulence
Biomedical Research
Research

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Management guidelines for laboratory exposures to agents of bioterrorism. / Rusnak, Janice M.; Kortepeter, Mark G.; Hawley, Robert J.; Boudreau, Ellen; Aldis, John; Pittman, Phillip R.

In: Journal of occupational and environmental medicine, Vol. 46, No. 8, 01.08.2004, p. 791-800.

Research output: Contribution to journalArticle

Rusnak, Janice M. ; Kortepeter, Mark G. ; Hawley, Robert J. ; Boudreau, Ellen ; Aldis, John ; Pittman, Phillip R. / Management guidelines for laboratory exposures to agents of bioterrorism. In: Journal of occupational and environmental medicine. 2004 ; Vol. 46, No. 8. pp. 791-800.
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