Mammary Analog Secretory Carcinoma (MASC) Involving the Thyroid Gland: A Report of the First 3 Cases

Jennifer Dettloff, Raja R. Seethala, Todd M. Stevens, Margaret Brandwein-Gensler, Barbara A. Centeno, Kristen Otto, Julia A. Bridge, Justin A. Bishop, Marino E. Leon

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Salivary gland-type tumors have been rarely described in the thyroid gland. Mammary Analog Secretory Carcinoma (MASC) is a recently defined type of salivary gland carcinoma characterized by a t(12;15)(p13;q25) resulting in an ETV6-NTRK3 fusion gene. We report 3 cases of MASC involving the thyroid gland without clinical evidence of a salivary gland or breast primary; the clinico-pathologic characteristics are reviewed. Assessment for rearrangement of the ETV6 (12p13) locus was conducted by fluorescence in situ hybridization (FISH) on representative FFPE sections using an ETV6 break apart probe (Abbott Molecular, Des Plaines, IL, USA). The patients were two females (52 and 55 years-old) and 1 male (74 years-old). The tumors were poorly circumscribed solid white tan nodules involving the thyroid. Histologically, they were invasive and showed solid, microcystic, cribriform, and tubular growth patterns composed of variably bland polygonal eosinophilic cells with vesicular nuclear chromatin and conspicuous nucleoli. All three cases showed metastasis to lymph nodes; one case showed lateral neck involvement. The tumor cells were positive for S100 and mammaglobin. GATA-3 and PAX-8 were positive in 2 cases, one of which only focally so. All three cases were negative for TTF-1 and thyroglobulin. Rearrangement of the ETV6 locus was confirmed in all cases and a diagnosis of MASC rendered for each case. A site of origin distinct from the thyroid gland was not identified, with a median follow up of 24 months. MASC may rarely involve the thyroid gland. The origin of these lesions is unknown; while an origin from ectopic salivary gland-type cells is entertained, a metastatic origin from an occult primary cannot be definitively excluded at this time. Given the histologic (follicular-like microcystic pattern with colloid-like secretions and papillary pattern), immunophenotypic (PAX-8), and even molecular overlap, MASC can be mistaken for papillary thyroid carcinoma and should be considered in the differential diagnosis of a thyroid mass.

Original languageEnglish (US)
Pages (from-to)124-130
Number of pages7
JournalHead and Neck Pathology
Volume11
Issue number2
DOIs
StatePublished - Jun 1 2017

Fingerprint

Thyroid Gland
Salivary Glands
Molecular Probes
Neoplasms
Thyroid Nodule
Thyroglobulin
Gene Fusion
Colloids
Fluorescence In Situ Hybridization
Chromatin
Breast
Differential Diagnosis
Neck
Lymph Nodes
Mammary Analogue Secretory Carcinoma
Neoplasm Metastasis
Carcinoma
Growth

Keywords

  • Adenocarcinomas
  • ETV6-NTRK3
  • Mammary analog secretory carcinoma
  • Salivary gland-type carcinomas
  • Thyroid

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Otorhinolaryngology
  • Oncology

Cite this

Dettloff, J., Seethala, R. R., Stevens, T. M., Brandwein-Gensler, M., Centeno, B. A., Otto, K., ... Leon, M. E. (2017). Mammary Analog Secretory Carcinoma (MASC) Involving the Thyroid Gland: A Report of the First 3 Cases. Head and Neck Pathology, 11(2), 124-130. https://doi.org/10.1007/s12105-016-0741-6

Mammary Analog Secretory Carcinoma (MASC) Involving the Thyroid Gland : A Report of the First 3 Cases. / Dettloff, Jennifer; Seethala, Raja R.; Stevens, Todd M.; Brandwein-Gensler, Margaret; Centeno, Barbara A.; Otto, Kristen; Bridge, Julia A.; Bishop, Justin A.; Leon, Marino E.

In: Head and Neck Pathology, Vol. 11, No. 2, 01.06.2017, p. 124-130.

Research output: Contribution to journalArticle

Dettloff, J, Seethala, RR, Stevens, TM, Brandwein-Gensler, M, Centeno, BA, Otto, K, Bridge, JA, Bishop, JA & Leon, ME 2017, 'Mammary Analog Secretory Carcinoma (MASC) Involving the Thyroid Gland: A Report of the First 3 Cases', Head and Neck Pathology, vol. 11, no. 2, pp. 124-130. https://doi.org/10.1007/s12105-016-0741-6
Dettloff J, Seethala RR, Stevens TM, Brandwein-Gensler M, Centeno BA, Otto K et al. Mammary Analog Secretory Carcinoma (MASC) Involving the Thyroid Gland: A Report of the First 3 Cases. Head and Neck Pathology. 2017 Jun 1;11(2):124-130. https://doi.org/10.1007/s12105-016-0741-6
Dettloff, Jennifer ; Seethala, Raja R. ; Stevens, Todd M. ; Brandwein-Gensler, Margaret ; Centeno, Barbara A. ; Otto, Kristen ; Bridge, Julia A. ; Bishop, Justin A. ; Leon, Marino E. / Mammary Analog Secretory Carcinoma (MASC) Involving the Thyroid Gland : A Report of the First 3 Cases. In: Head and Neck Pathology. 2017 ; Vol. 11, No. 2. pp. 124-130.
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