Malignant paraganglioma of the bladder: A case report and review of the literature

Erin E. Quist, Barry M. Javadzadeh, Eric Johannesen, Sonny L. Johansson, Subodh M. Lele, Jessica A. Kozel

Research output: Contribution to journalArticle

Abstract

Although paragangliomas of the bladder are uncommon, malignant paragangliomas of this anatomic site are exceedingly rare, with a mere 37 previously reported cases. We report the case of a 58-year-old man with a malignant paraganglioma of the bladder who sought care secondary to gross hematuria; however, misdiagnosis of this tumor resulted in hypertensive crisis during cystoprostatectomy. Not only does this case present a unique malignant paraganglioma of the bladder, but also it discusses the clinical ramifications when misdiagnosed. Like pheochromocytomas, extra-adrenal paragangliomas can manifest with similar sympathetic stimulation; this becomes a serious complication for clinicians resecting these tumors in unusual locations without proper histologic diagnosis. Additionally, we discuss the unique clinical and pathologic findings of our patient and comprehensively review the previously published cases comparing clinical and pathologic features. Several interesting findings are identified including average age at diagnosis, gender predilection, presenting symptoms, size at diagnosis, and common sites of metastasis.

Original languageEnglish (US)
Pages (from-to)183-188
Number of pages6
JournalPathology Research and Practice
Volume211
Issue number2
DOIs
StatePublished - Feb 1 2015

Fingerprint

Paraganglioma
Urinary Bladder
Diagnostic Errors
Extra-Adrenal Paraganglioma
Secondary Care
Pheochromocytoma
Hematuria
Neoplasms
Neoplasm Metastasis

Keywords

  • Malignant paraganglioma
  • Paraganglioma
  • Paraganglioma of urinary bladder

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Cell Biology

Cite this

Quist, E. E., Javadzadeh, B. M., Johannesen, E., Johansson, S. L., Lele, S. M., & Kozel, J. A. (2015). Malignant paraganglioma of the bladder: A case report and review of the literature. Pathology Research and Practice, 211(2), 183-188. https://doi.org/10.1016/j.prp.2014.10.009

Malignant paraganglioma of the bladder : A case report and review of the literature. / Quist, Erin E.; Javadzadeh, Barry M.; Johannesen, Eric; Johansson, Sonny L.; Lele, Subodh M.; Kozel, Jessica A.

In: Pathology Research and Practice, Vol. 211, No. 2, 01.02.2015, p. 183-188.

Research output: Contribution to journalArticle

Quist, EE, Javadzadeh, BM, Johannesen, E, Johansson, SL, Lele, SM & Kozel, JA 2015, 'Malignant paraganglioma of the bladder: A case report and review of the literature', Pathology Research and Practice, vol. 211, no. 2, pp. 183-188. https://doi.org/10.1016/j.prp.2014.10.009
Quist EE, Javadzadeh BM, Johannesen E, Johansson SL, Lele SM, Kozel JA. Malignant paraganglioma of the bladder: A case report and review of the literature. Pathology Research and Practice. 2015 Feb 1;211(2):183-188. https://doi.org/10.1016/j.prp.2014.10.009
Quist, Erin E. ; Javadzadeh, Barry M. ; Johannesen, Eric ; Johansson, Sonny L. ; Lele, Subodh M. ; Kozel, Jessica A. / Malignant paraganglioma of the bladder : A case report and review of the literature. In: Pathology Research and Practice. 2015 ; Vol. 211, No. 2. pp. 183-188.
@article{069ad9ee157d44efb386ef4150f602f0,
title = "Malignant paraganglioma of the bladder: A case report and review of the literature",
abstract = "Although paragangliomas of the bladder are uncommon, malignant paragangliomas of this anatomic site are exceedingly rare, with a mere 37 previously reported cases. We report the case of a 58-year-old man with a malignant paraganglioma of the bladder who sought care secondary to gross hematuria; however, misdiagnosis of this tumor resulted in hypertensive crisis during cystoprostatectomy. Not only does this case present a unique malignant paraganglioma of the bladder, but also it discusses the clinical ramifications when misdiagnosed. Like pheochromocytomas, extra-adrenal paragangliomas can manifest with similar sympathetic stimulation; this becomes a serious complication for clinicians resecting these tumors in unusual locations without proper histologic diagnosis. Additionally, we discuss the unique clinical and pathologic findings of our patient and comprehensively review the previously published cases comparing clinical and pathologic features. Several interesting findings are identified including average age at diagnosis, gender predilection, presenting symptoms, size at diagnosis, and common sites of metastasis.",
keywords = "Malignant paraganglioma, Paraganglioma, Paraganglioma of urinary bladder",
author = "Quist, {Erin E.} and Javadzadeh, {Barry M.} and Eric Johannesen and Johansson, {Sonny L.} and Lele, {Subodh M.} and Kozel, {Jessica A.}",
year = "2015",
month = "2",
day = "1",
doi = "10.1016/j.prp.2014.10.009",
language = "English (US)",
volume = "211",
pages = "183--188",
journal = "Pathology Research and Practice",
issn = "0344-0338",
publisher = "Urban und Fischer Verlag GmbH und Co. KG",
number = "2",

}

TY - JOUR

T1 - Malignant paraganglioma of the bladder

T2 - A case report and review of the literature

AU - Quist, Erin E.

AU - Javadzadeh, Barry M.

AU - Johannesen, Eric

AU - Johansson, Sonny L.

AU - Lele, Subodh M.

AU - Kozel, Jessica A.

PY - 2015/2/1

Y1 - 2015/2/1

N2 - Although paragangliomas of the bladder are uncommon, malignant paragangliomas of this anatomic site are exceedingly rare, with a mere 37 previously reported cases. We report the case of a 58-year-old man with a malignant paraganglioma of the bladder who sought care secondary to gross hematuria; however, misdiagnosis of this tumor resulted in hypertensive crisis during cystoprostatectomy. Not only does this case present a unique malignant paraganglioma of the bladder, but also it discusses the clinical ramifications when misdiagnosed. Like pheochromocytomas, extra-adrenal paragangliomas can manifest with similar sympathetic stimulation; this becomes a serious complication for clinicians resecting these tumors in unusual locations without proper histologic diagnosis. Additionally, we discuss the unique clinical and pathologic findings of our patient and comprehensively review the previously published cases comparing clinical and pathologic features. Several interesting findings are identified including average age at diagnosis, gender predilection, presenting symptoms, size at diagnosis, and common sites of metastasis.

AB - Although paragangliomas of the bladder are uncommon, malignant paragangliomas of this anatomic site are exceedingly rare, with a mere 37 previously reported cases. We report the case of a 58-year-old man with a malignant paraganglioma of the bladder who sought care secondary to gross hematuria; however, misdiagnosis of this tumor resulted in hypertensive crisis during cystoprostatectomy. Not only does this case present a unique malignant paraganglioma of the bladder, but also it discusses the clinical ramifications when misdiagnosed. Like pheochromocytomas, extra-adrenal paragangliomas can manifest with similar sympathetic stimulation; this becomes a serious complication for clinicians resecting these tumors in unusual locations without proper histologic diagnosis. Additionally, we discuss the unique clinical and pathologic findings of our patient and comprehensively review the previously published cases comparing clinical and pathologic features. Several interesting findings are identified including average age at diagnosis, gender predilection, presenting symptoms, size at diagnosis, and common sites of metastasis.

KW - Malignant paraganglioma

KW - Paraganglioma

KW - Paraganglioma of urinary bladder

UR - http://www.scopus.com/inward/record.url?scp=84922939418&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84922939418&partnerID=8YFLogxK

U2 - 10.1016/j.prp.2014.10.009

DO - 10.1016/j.prp.2014.10.009

M3 - Article

C2 - 25512259

VL - 211

SP - 183

EP - 188

JO - Pathology Research and Practice

JF - Pathology Research and Practice

SN - 0344-0338

IS - 2

ER -