Maintaining K+ balance on the low-Na+, high-K+ diet

Ryan J. Cornelius, Bangchen Wang, Jun Wang-France, Steven Claude Sansom

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

A low-Na+, high-K+diet (LNaHK) is considered a healthier alternative to the “Western” high-Na+ diet. Because the mechanism for K+ secretion involves Na+ reabsorptive exchange for secreted K+ in the distal nephron, it is not understood how K+ is eliminated with such low Na+ intake. Animals on a LNaHK diet produce an alkaline load, high urinary flows, and markedly elevated plasma ANG II and aldosterone levels to maintain their K+ balance. Recent studies have revealed a potential mechanism involving the actions of alkalosis, urinary flow, elevated ANG II, and aldosterone on two types of K+ channels, renal outer medullary K+ and large-conductance K+ channels, located in principal and intercalated cells. Here, we review these recent advances.

Original languageEnglish (US)
Pages (from-to)F581-F595
JournalAmerican Journal of Physiology - Renal Physiology
Volume310
Issue number7
DOIs
StatePublished - Apr 1 2016

Fingerprint

Diet
Aldosterone
Alkalosis
Nephrons
Kidney

Keywords

  • Angiotensin II
  • Epithelial Na channel
  • Largeconductance K channel
  • Na-Clcotransporter
  • Renal outer medullary K channel

ASJC Scopus subject areas

  • Physiology
  • Urology

Cite this

Maintaining K+ balance on the low-Na+, high-K+ diet. / Cornelius, Ryan J.; Wang, Bangchen; Wang-France, Jun; Sansom, Steven Claude.

In: American Journal of Physiology - Renal Physiology, Vol. 310, No. 7, 01.04.2016, p. F581-F595.

Research output: Contribution to journalReview article

Cornelius, Ryan J. ; Wang, Bangchen ; Wang-France, Jun ; Sansom, Steven Claude. / Maintaining K+ balance on the low-Na+, high-K+ diet. In: American Journal of Physiology - Renal Physiology. 2016 ; Vol. 310, No. 7. pp. F581-F595.
@article{416302f73a51403aba04d0d151c7025b,
title = "Maintaining K+ balance on the low-Na+, high-K+ diet",
abstract = "A low-Na+, high-K+diet (LNaHK) is considered a healthier alternative to the “Western” high-Na+ diet. Because the mechanism for K+ secretion involves Na+ reabsorptive exchange for secreted K+ in the distal nephron, it is not understood how K+ is eliminated with such low Na+ intake. Animals on a LNaHK diet produce an alkaline load, high urinary flows, and markedly elevated plasma ANG II and aldosterone levels to maintain their K+ balance. Recent studies have revealed a potential mechanism involving the actions of alkalosis, urinary flow, elevated ANG II, and aldosterone on two types of K+ channels, renal outer medullary K+ and large-conductance K+ channels, located in principal and intercalated cells. Here, we review these recent advances.",
keywords = "Angiotensin II, Epithelial Na channel, Largeconductance K channel, Na-Clcotransporter, Renal outer medullary K channel",
author = "Cornelius, {Ryan J.} and Bangchen Wang and Jun Wang-France and Sansom, {Steven Claude}",
year = "2016",
month = "4",
day = "1",
doi = "10.1152/ajprenal.00330.2015",
language = "English (US)",
volume = "310",
pages = "F581--F595",
journal = "American Journal of Physiology - Renal Physiology",
issn = "0363-6127",
publisher = "American Physiological Society",
number = "7",

}

TY - JOUR

T1 - Maintaining K+ balance on the low-Na+, high-K+ diet

AU - Cornelius, Ryan J.

AU - Wang, Bangchen

AU - Wang-France, Jun

AU - Sansom, Steven Claude

PY - 2016/4/1

Y1 - 2016/4/1

N2 - A low-Na+, high-K+diet (LNaHK) is considered a healthier alternative to the “Western” high-Na+ diet. Because the mechanism for K+ secretion involves Na+ reabsorptive exchange for secreted K+ in the distal nephron, it is not understood how K+ is eliminated with such low Na+ intake. Animals on a LNaHK diet produce an alkaline load, high urinary flows, and markedly elevated plasma ANG II and aldosterone levels to maintain their K+ balance. Recent studies have revealed a potential mechanism involving the actions of alkalosis, urinary flow, elevated ANG II, and aldosterone on two types of K+ channels, renal outer medullary K+ and large-conductance K+ channels, located in principal and intercalated cells. Here, we review these recent advances.

AB - A low-Na+, high-K+diet (LNaHK) is considered a healthier alternative to the “Western” high-Na+ diet. Because the mechanism for K+ secretion involves Na+ reabsorptive exchange for secreted K+ in the distal nephron, it is not understood how K+ is eliminated with such low Na+ intake. Animals on a LNaHK diet produce an alkaline load, high urinary flows, and markedly elevated plasma ANG II and aldosterone levels to maintain their K+ balance. Recent studies have revealed a potential mechanism involving the actions of alkalosis, urinary flow, elevated ANG II, and aldosterone on two types of K+ channels, renal outer medullary K+ and large-conductance K+ channels, located in principal and intercalated cells. Here, we review these recent advances.

KW - Angiotensin II

KW - Epithelial Na channel

KW - Largeconductance K channel

KW - Na-Clcotransporter

KW - Renal outer medullary K channel

UR - http://www.scopus.com/inward/record.url?scp=84984649941&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84984649941&partnerID=8YFLogxK

U2 - 10.1152/ajprenal.00330.2015

DO - 10.1152/ajprenal.00330.2015

M3 - Review article

VL - 310

SP - F581-F595

JO - American Journal of Physiology - Renal Physiology

JF - American Journal of Physiology - Renal Physiology

SN - 0363-6127

IS - 7

ER -