Main autopsy findings in liver transplant patients.

Rodney Smith Markin, S. Hollins, R. P. Wood, B. W. Shaw

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The major autopsy findings from 22 patients (6 children, 16 adults) having undergone therapeutic orthotopic liver transplant are summarized. The mean age for children was 4.2 yr (range 4 mo to 9 yr) and 41 yr (range 20 to 57 yr) for adults. The mean posttransplant survival time in these patients was 16.7 d for children and 72.5 d for adults. The changes present in hepatic allograft included graft rejection (13), viral infections (11), massive necrosis due to hepatic arterial thrombosis (6), and recurrent hepatitis B (3). Infectious complications were present in 20 of 22 patients. The extrahepatic organs primarily involved by infection were lungs and brain. Bronchopneumonia and abscess formation were the most common lung findings, whereas cerebral edema and herniation, and infection occurred in the brain. Cardiac findings included acute myocardial infarction, mycotic mural thrombus and cytomegalovirus myocarditis. The gastrointestinal tract, adrenals, and kidneys were virtually spared. No significant changes were found in the pancreas and urogenital tract.

Original languageEnglish (US)
Pages (from-to)339-348
Number of pages10
JournalModern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Volume2
Issue number4
StatePublished - Jan 1 1989

Fingerprint

Autopsy
Transplants
Liver
Thrombosis
Bronchopneumonia
Lung
Brain Edema
Myocarditis
Brain
Graft Rejection
Virus Diseases
Infection
Hepatitis B
Cytomegalovirus
Abscess
Allografts
Gastrointestinal Tract
Pancreas
Necrosis
Survival Rate

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Main autopsy findings in liver transplant patients. / Markin, Rodney Smith; Hollins, S.; Wood, R. P.; Shaw, B. W.

In: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, Vol. 2, No. 4, 01.01.1989, p. 339-348.

Research output: Contribution to journalArticle

@article{3767a52b877341529960b52fe7567128,
title = "Main autopsy findings in liver transplant patients.",
abstract = "The major autopsy findings from 22 patients (6 children, 16 adults) having undergone therapeutic orthotopic liver transplant are summarized. The mean age for children was 4.2 yr (range 4 mo to 9 yr) and 41 yr (range 20 to 57 yr) for adults. The mean posttransplant survival time in these patients was 16.7 d for children and 72.5 d for adults. The changes present in hepatic allograft included graft rejection (13), viral infections (11), massive necrosis due to hepatic arterial thrombosis (6), and recurrent hepatitis B (3). Infectious complications were present in 20 of 22 patients. The extrahepatic organs primarily involved by infection were lungs and brain. Bronchopneumonia and abscess formation were the most common lung findings, whereas cerebral edema and herniation, and infection occurred in the brain. Cardiac findings included acute myocardial infarction, mycotic mural thrombus and cytomegalovirus myocarditis. The gastrointestinal tract, adrenals, and kidneys were virtually spared. No significant changes were found in the pancreas and urogenital tract.",
author = "Markin, {Rodney Smith} and S. Hollins and Wood, {R. P.} and Shaw, {B. W.}",
year = "1989",
month = "1",
day = "1",
language = "English (US)",
volume = "2",
pages = "339--348",
journal = "Modern Pathology",
issn = "0893-3952",
publisher = "Nature Publishing Group",
number = "4",

}

TY - JOUR

T1 - Main autopsy findings in liver transplant patients.

AU - Markin, Rodney Smith

AU - Hollins, S.

AU - Wood, R. P.

AU - Shaw, B. W.

PY - 1989/1/1

Y1 - 1989/1/1

N2 - The major autopsy findings from 22 patients (6 children, 16 adults) having undergone therapeutic orthotopic liver transplant are summarized. The mean age for children was 4.2 yr (range 4 mo to 9 yr) and 41 yr (range 20 to 57 yr) for adults. The mean posttransplant survival time in these patients was 16.7 d for children and 72.5 d for adults. The changes present in hepatic allograft included graft rejection (13), viral infections (11), massive necrosis due to hepatic arterial thrombosis (6), and recurrent hepatitis B (3). Infectious complications were present in 20 of 22 patients. The extrahepatic organs primarily involved by infection were lungs and brain. Bronchopneumonia and abscess formation were the most common lung findings, whereas cerebral edema and herniation, and infection occurred in the brain. Cardiac findings included acute myocardial infarction, mycotic mural thrombus and cytomegalovirus myocarditis. The gastrointestinal tract, adrenals, and kidneys were virtually spared. No significant changes were found in the pancreas and urogenital tract.

AB - The major autopsy findings from 22 patients (6 children, 16 adults) having undergone therapeutic orthotopic liver transplant are summarized. The mean age for children was 4.2 yr (range 4 mo to 9 yr) and 41 yr (range 20 to 57 yr) for adults. The mean posttransplant survival time in these patients was 16.7 d for children and 72.5 d for adults. The changes present in hepatic allograft included graft rejection (13), viral infections (11), massive necrosis due to hepatic arterial thrombosis (6), and recurrent hepatitis B (3). Infectious complications were present in 20 of 22 patients. The extrahepatic organs primarily involved by infection were lungs and brain. Bronchopneumonia and abscess formation were the most common lung findings, whereas cerebral edema and herniation, and infection occurred in the brain. Cardiac findings included acute myocardial infarction, mycotic mural thrombus and cytomegalovirus myocarditis. The gastrointestinal tract, adrenals, and kidneys were virtually spared. No significant changes were found in the pancreas and urogenital tract.

UR - http://www.scopus.com/inward/record.url?scp=0024695791&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024695791&partnerID=8YFLogxK

M3 - Article

VL - 2

SP - 339

EP - 348

JO - Modern Pathology

JF - Modern Pathology

SN - 0893-3952

IS - 4

ER -