Magnetoencephalography reveals altered auditory information processing in youth with obsessive-compulsive disorder

Milena Korostenskaja, Elana Harris, Cathy Giovanetti, Paul Horn, Yingying Wang, Douglas Rose, Hisako Fujiwara, Jing Xiang

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Patients with obsessive-compulsive disorder (OCD) often report sensory intolerances which may lead to significant functional impairment. This study used auditory evoked fields (AEFs) to address the question of whether neural correlates of sensory auditory information processing differ in youth with OCD compared with healthy comparison subjects (HCS). AEFs, recorded with a whole head 275-channel magnetoencephalography system, were elicited in response to binaural auditory stimuli from 10 pediatric subjects with OCD (ages 8-13, mean 11 years, 6 males) and 10 age- and gender-matched HCS. Three major neuromagnetic responses were studied: M70 (60-80 ms), M100 (90-120 ms), and M150 (130-190. ms). When compared with HCS, subjects with OCD demonstrated delayed latency of the M100 response. In subjects with OCD the amplitude of the M100 and M150 responses was significantly greater in the right hemisphere compared with the left hemisphere. Current results suggest that when compared with HCS, subjects with OCD have altered auditory information processing, evident from the delayed latency of the M100 response, which is thought to be associated with the encoding of physical stimulus characteristics. Interhemispheric asymmetry with increased M100 and M150 amplitudes over the right hemisphere compared with the left hemisphere was found in young OCD subjects. These results should be interpreted with caution due to the high variability rate of responses in both HCS and OCD subjects, as well as the possible effect of medication in OCD subjects.

Original languageEnglish (US)
Pages (from-to)132-140
Number of pages9
JournalPsychiatry Research - Neuroimaging
Volume212
Issue number2
DOIs
StatePublished - May 30 2013

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Magnetoencephalography
Obsessive-Compulsive Disorder
Automatic Data Processing
Healthy Volunteers
Reaction Time
Head
Pediatrics

Keywords

  • Auditory evoked fields (AEFs)
  • Auditory evoked potentials (AEPs)
  • Event-related fields (ERFs)
  • Event-related potentials (ERPs)
  • M100
  • Obsessive-compulsive disorder (OCD)

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Psychiatry and Mental health

Cite this

Magnetoencephalography reveals altered auditory information processing in youth with obsessive-compulsive disorder. / Korostenskaja, Milena; Harris, Elana; Giovanetti, Cathy; Horn, Paul; Wang, Yingying; Rose, Douglas; Fujiwara, Hisako; Xiang, Jing.

In: Psychiatry Research - Neuroimaging, Vol. 212, No. 2, 30.05.2013, p. 132-140.

Research output: Contribution to journalArticle

Korostenskaja, Milena ; Harris, Elana ; Giovanetti, Cathy ; Horn, Paul ; Wang, Yingying ; Rose, Douglas ; Fujiwara, Hisako ; Xiang, Jing. / Magnetoencephalography reveals altered auditory information processing in youth with obsessive-compulsive disorder. In: Psychiatry Research - Neuroimaging. 2013 ; Vol. 212, No. 2. pp. 132-140.
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