Abstract
Magnetic responsive particles were designed for use in oral delivery of insulin. Magnetite nanoparticles (12 nm average size) were synthesized and co-encapsulated with insulin into poly(lactide-co-glycolide) (PLGA) microparticles (4.6 ± 2.2 μm average particle size) through the double-emulsion method, The spherical structures of resulting microparticles were well maintained at magnetite content 5 wt % or less. Mice were gavaged with 125I-insulin-magnetite-PLGA microparticles and a circumferential trans-abdominal magnetic field was applied forty minutes after administration to retard the transit of the microparticles in the intestinal tract. As control, mice were similarly dosed without the subsequent trans-abdominal magnetic field. Mice were sacrificed, and the intestinal radioactivity was 101% and 145% higher in treated mice versus the control at 6 h and 12 h, respectively. A single administration of 50 unit/kg Humulin R-magnetite-PLGA microparticles to the fasted mice resulted in 66% reduction of blood glucose level in the presence of external magnetic field at 12 h, compared to 27% reduction in the absence of magnetic field,
| Original language | English (US) |
|---|---|
| Title of host publication | Biological and Bio-Inspired Materials and Devices |
| Pages | 109-114 |
| Number of pages | 6 |
| State | Published - Dec 1 2005 |
| Event | 2005 MRS Spring Meeting - San Francisco, CA, United States Duration: Mar 28 2005 → Apr 1 2005 |
Publication series
| Name | Materials Research Society Symposium Proceedings |
|---|---|
| Volume | 873 |
| ISSN (Print) | 0272-9172 |
Other
| Other | 2005 MRS Spring Meeting |
|---|---|
| Country | United States |
| City | San Francisco, CA |
| Period | 3/28/05 → 4/1/05 |
Fingerprint
ASJC Scopus subject areas
- Materials Science(all)
- Condensed Matter Physics
- Mechanics of Materials
- Mechanical Engineering
Cite this
Magnetite-PLGA microparticles for oral delivery of insulin. / Cheng, Jianjun; Yim, Christopher H.; Teply, Benjamin A.; Ho, Dennis; Farokhzad, Omid C.; Langer, Robert S.
Biological and Bio-Inspired Materials and Devices. 2005. p. 109-114 (Materials Research Society Symposium Proceedings; Vol. 873).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Magnetite-PLGA microparticles for oral delivery of insulin
AU - Cheng, Jianjun
AU - Yim, Christopher H.
AU - Teply, Benjamin A.
AU - Ho, Dennis
AU - Farokhzad, Omid C.
AU - Langer, Robert S.
PY - 2005/12/1
Y1 - 2005/12/1
N2 - Magnetic responsive particles were designed for use in oral delivery of insulin. Magnetite nanoparticles (12 nm average size) were synthesized and co-encapsulated with insulin into poly(lactide-co-glycolide) (PLGA) microparticles (4.6 ± 2.2 μm average particle size) through the double-emulsion method, The spherical structures of resulting microparticles were well maintained at magnetite content 5 wt % or less. Mice were gavaged with 125I-insulin-magnetite-PLGA microparticles and a circumferential trans-abdominal magnetic field was applied forty minutes after administration to retard the transit of the microparticles in the intestinal tract. As control, mice were similarly dosed without the subsequent trans-abdominal magnetic field. Mice were sacrificed, and the intestinal radioactivity was 101% and 145% higher in treated mice versus the control at 6 h and 12 h, respectively. A single administration of 50 unit/kg Humulin R-magnetite-PLGA microparticles to the fasted mice resulted in 66% reduction of blood glucose level in the presence of external magnetic field at 12 h, compared to 27% reduction in the absence of magnetic field,
AB - Magnetic responsive particles were designed for use in oral delivery of insulin. Magnetite nanoparticles (12 nm average size) were synthesized and co-encapsulated with insulin into poly(lactide-co-glycolide) (PLGA) microparticles (4.6 ± 2.2 μm average particle size) through the double-emulsion method, The spherical structures of resulting microparticles were well maintained at magnetite content 5 wt % or less. Mice were gavaged with 125I-insulin-magnetite-PLGA microparticles and a circumferential trans-abdominal magnetic field was applied forty minutes after administration to retard the transit of the microparticles in the intestinal tract. As control, mice were similarly dosed without the subsequent trans-abdominal magnetic field. Mice were sacrificed, and the intestinal radioactivity was 101% and 145% higher in treated mice versus the control at 6 h and 12 h, respectively. A single administration of 50 unit/kg Humulin R-magnetite-PLGA microparticles to the fasted mice resulted in 66% reduction of blood glucose level in the presence of external magnetic field at 12 h, compared to 27% reduction in the absence of magnetic field,
UR - http://www.scopus.com/inward/record.url?scp=34249950077&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34249950077&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:34249950077
SN - 1558998276
SN - 9781558998278
T3 - Materials Research Society Symposium Proceedings
SP - 109
EP - 114
BT - Biological and Bio-Inspired Materials and Devices
ER -