Magnetic resonance imaging findings of term and preterm hypoxic-ischemic encephalopathy: A review of relevant animal models and correlation to human imaging

Kyle A. Jisa, Dillon D. Clarey, Eric S. Peeples

Research output: Contribution to journalReview article

Abstract

Background: Neonatal hypoxic-ischemic encephalopathy is brain injury caused by decreased perfusion and oxygen delivery that most commonly occurs in the context of delivery complications such as umbilical cord compression or placental abruption. Imaging is a key component for guiding treatment and prediction of prognosis, and the most sensitive clinical imaging modality for the brain injury patterns seen in hypoxic-ischemic encephalopathy is magnetic resonance imaging. Objective: The goal of this review is to compare magnetic resonance imaging findings demonstrated in the available animal models of hypoxic-ischemic encephalopathy to those found in preterm (≤ 36 weeks) and term (>36 weeks) human neonates with hypoxic-ischemic encephalopathy, with special attention to the strengths and weaknesses of each model. Methods: A structured literature search was performed independently by two authors and the results of the searches were compiled. Animal model, human brain age equivalency, mechanism of injury, and area of brain injury were recorded for comparison to imaging findings in preterm and term human neonates with hypoxic-ischemic encephalopathy. Conclusion: Numerous animal models have been developed to better elicit the expected findings that occur after HIE by allowing investigators to control many of the clinical variables that result in injury. Although modeling the same disease process, magnetic resonance imaging findings in the animal models vary with the species and methods used to induce hypoxia and ischemia. The further development of animal models of HIE should include a focus on comparing imaging findings, and not just pathologic findings, to human studies.

Original languageEnglish (US)
Pages (from-to)55-65
Number of pages11
JournalOpen Neuroimaging Journal
Volume12
Issue number1
DOIs
StatePublished - Jan 1 2018

Fingerprint

Brain Hypoxia-Ischemia
Animal Models
Magnetic Resonance Imaging
Brain Injuries
Abruptio Placentae
Umbilical Cord
Wounds and Injuries
Ischemia
Perfusion
Research Personnel
Oxygen
Brain

Keywords

  • Asphyxia
  • Brain injury
  • Mouse
  • Neonate
  • Non-human primate
  • Rabbit
  • Rat
  • Sheep

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology

Cite this

Magnetic resonance imaging findings of term and preterm hypoxic-ischemic encephalopathy : A review of relevant animal models and correlation to human imaging. / Jisa, Kyle A.; Clarey, Dillon D.; Peeples, Eric S.

In: Open Neuroimaging Journal, Vol. 12, No. 1, 01.01.2018, p. 55-65.

Research output: Contribution to journalReview article

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