Macular sensitivity and fixation patterns in normal eyes and eyes with uveitis with and without macular edema

Yasir J. Sepah, Elham Hatef, Elizabeth Colantuoni, Jianmin Wang, Mathew Shulman, Fatima Idrees Adhi, Abeer Akhtar, Mohamed Ibrahim, Afsheen Khwaja, Roomasa Channa, Raafay Sophie, Millena Bittencourt, Jangwon Heo, Diana V Do, Quan Dong Nguyen

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Purpose: This study aims to investigate the relationship between macular sensitivity and thickness in eyes with uveitic macular edema (UME). Design: This study is a prospective observational case series. Methods: The setting for this study was clinical practice. The study included 59 (28 with UME, 31 without UME) eyes of 26 patients with uveitis and 19 eyes of 10 normal subjects. The procedure followed was fundus-related perimetry and retinal thickness map with an automated fundus perimetry/tomography system. Main outcome measures included quantification of macular sensitivity, fixation pattern, and relationship between macular sensitivity and thickness. Results: Fixation stability revealed that 56 eyes (93.44%) had stable fixation (>75% within the central 2° of point of fixation); three eyes (6.56%) were relatively unstable (<75% of fixation points located within 2°, >75% located within 4°); and no eye had unstable fixation (<75% of fixation points located within 4°). Evaluation of fixation location revealed that 45 eyes (76.27%) had central fixation location (>50% of fixation point within 0.5 mm of foveal center); seven eyes (11.86%) had peri-central fixation location (25% << 50% within 0.5 mm); and seven eyes (11.86%) had eccentric (<25% of fixation point within 0.5 mm) fixation location. We measured macular sensitivity and corresponding thickness in 1,708 loci of 61 study eyes. Macular sensitivity increased by 0.02 dB (95% confidence interval, 0.00, 0.06) per 1 μm increase in the thickness for the thickness values ≤280 μm. Macular sensitivity decreased by 0.04 dB (95% CI, -0.08, -0.01) per 1 μm increase in the thickness for the thickness values >280 μm. Conclusions: Perimetry quantification of macular sensitivity and retinal thickness, in association with other factors, may offer novel information regarding the impact of UME on retinal function.

Original languageEnglish (US)
Pages (from-to)65-73
Number of pages9
JournalJournal of Ophthalmic Inflammation and Infection
Volume2
Issue number2
DOIs
StatePublished - Jun 1 2012

Fingerprint

Macular Edema
Uveitis
Visual Field Tests
Tomography
Outcome Assessment (Health Care)

Keywords

  • Microperimetry
  • Retinal thickness
  • Uveitic macular edema
  • Uveitis

ASJC Scopus subject areas

  • Ophthalmology
  • Infectious Diseases

Cite this

Macular sensitivity and fixation patterns in normal eyes and eyes with uveitis with and without macular edema. / Sepah, Yasir J.; Hatef, Elham; Colantuoni, Elizabeth; Wang, Jianmin; Shulman, Mathew; Adhi, Fatima Idrees; Akhtar, Abeer; Ibrahim, Mohamed; Khwaja, Afsheen; Channa, Roomasa; Sophie, Raafay; Bittencourt, Millena; Heo, Jangwon; Do, Diana V; Nguyen, Quan Dong.

In: Journal of Ophthalmic Inflammation and Infection, Vol. 2, No. 2, 01.06.2012, p. 65-73.

Research output: Contribution to journalArticle

Sepah, YJ, Hatef, E, Colantuoni, E, Wang, J, Shulman, M, Adhi, FI, Akhtar, A, Ibrahim, M, Khwaja, A, Channa, R, Sophie, R, Bittencourt, M, Heo, J, Do, DV & Nguyen, QD 2012, 'Macular sensitivity and fixation patterns in normal eyes and eyes with uveitis with and without macular edema', Journal of Ophthalmic Inflammation and Infection, vol. 2, no. 2, pp. 65-73. https://doi.org/10.1007/s12348-011-0052-8
Sepah, Yasir J. ; Hatef, Elham ; Colantuoni, Elizabeth ; Wang, Jianmin ; Shulman, Mathew ; Adhi, Fatima Idrees ; Akhtar, Abeer ; Ibrahim, Mohamed ; Khwaja, Afsheen ; Channa, Roomasa ; Sophie, Raafay ; Bittencourt, Millena ; Heo, Jangwon ; Do, Diana V ; Nguyen, Quan Dong. / Macular sensitivity and fixation patterns in normal eyes and eyes with uveitis with and without macular edema. In: Journal of Ophthalmic Inflammation and Infection. 2012 ; Vol. 2, No. 2. pp. 65-73.
@article{ed794c5956684ec3a145b9d679ab4b17,
title = "Macular sensitivity and fixation patterns in normal eyes and eyes with uveitis with and without macular edema",
abstract = "Purpose: This study aims to investigate the relationship between macular sensitivity and thickness in eyes with uveitic macular edema (UME). Design: This study is a prospective observational case series. Methods: The setting for this study was clinical practice. The study included 59 (28 with UME, 31 without UME) eyes of 26 patients with uveitis and 19 eyes of 10 normal subjects. The procedure followed was fundus-related perimetry and retinal thickness map with an automated fundus perimetry/tomography system. Main outcome measures included quantification of macular sensitivity, fixation pattern, and relationship between macular sensitivity and thickness. Results: Fixation stability revealed that 56 eyes (93.44{\%}) had stable fixation (>75{\%} within the central 2° of point of fixation); three eyes (6.56{\%}) were relatively unstable (<75{\%} of fixation points located within 2°, >75{\%} located within 4°); and no eye had unstable fixation (<75{\%} of fixation points located within 4°). Evaluation of fixation location revealed that 45 eyes (76.27{\%}) had central fixation location (>50{\%} of fixation point within 0.5 mm of foveal center); seven eyes (11.86{\%}) had peri-central fixation location (25{\%} << 50{\%} within 0.5 mm); and seven eyes (11.86{\%}) had eccentric (<25{\%} of fixation point within 0.5 mm) fixation location. We measured macular sensitivity and corresponding thickness in 1,708 loci of 61 study eyes. Macular sensitivity increased by 0.02 dB (95{\%} confidence interval, 0.00, 0.06) per 1 μm increase in the thickness for the thickness values ≤280 μm. Macular sensitivity decreased by 0.04 dB (95{\%} CI, -0.08, -0.01) per 1 μm increase in the thickness for the thickness values >280 μm. Conclusions: Perimetry quantification of macular sensitivity and retinal thickness, in association with other factors, may offer novel information regarding the impact of UME on retinal function.",
keywords = "Microperimetry, Retinal thickness, Uveitic macular edema, Uveitis",
author = "Sepah, {Yasir J.} and Elham Hatef and Elizabeth Colantuoni and Jianmin Wang and Mathew Shulman and Adhi, {Fatima Idrees} and Abeer Akhtar and Mohamed Ibrahim and Afsheen Khwaja and Roomasa Channa and Raafay Sophie and Millena Bittencourt and Jangwon Heo and Do, {Diana V} and Nguyen, {Quan Dong}",
year = "2012",
month = "6",
day = "1",
doi = "10.1007/s12348-011-0052-8",
language = "English (US)",
volume = "2",
pages = "65--73",
journal = "Journal of Ophthalmic Inflammation and Infection",
issn = "1869-5760",
publisher = "Springer Verlag",
number = "2",

}

TY - JOUR

T1 - Macular sensitivity and fixation patterns in normal eyes and eyes with uveitis with and without macular edema

AU - Sepah, Yasir J.

AU - Hatef, Elham

AU - Colantuoni, Elizabeth

AU - Wang, Jianmin

AU - Shulman, Mathew

AU - Adhi, Fatima Idrees

AU - Akhtar, Abeer

AU - Ibrahim, Mohamed

AU - Khwaja, Afsheen

AU - Channa, Roomasa

AU - Sophie, Raafay

AU - Bittencourt, Millena

AU - Heo, Jangwon

AU - Do, Diana V

AU - Nguyen, Quan Dong

PY - 2012/6/1

Y1 - 2012/6/1

N2 - Purpose: This study aims to investigate the relationship between macular sensitivity and thickness in eyes with uveitic macular edema (UME). Design: This study is a prospective observational case series. Methods: The setting for this study was clinical practice. The study included 59 (28 with UME, 31 without UME) eyes of 26 patients with uveitis and 19 eyes of 10 normal subjects. The procedure followed was fundus-related perimetry and retinal thickness map with an automated fundus perimetry/tomography system. Main outcome measures included quantification of macular sensitivity, fixation pattern, and relationship between macular sensitivity and thickness. Results: Fixation stability revealed that 56 eyes (93.44%) had stable fixation (>75% within the central 2° of point of fixation); three eyes (6.56%) were relatively unstable (<75% of fixation points located within 2°, >75% located within 4°); and no eye had unstable fixation (<75% of fixation points located within 4°). Evaluation of fixation location revealed that 45 eyes (76.27%) had central fixation location (>50% of fixation point within 0.5 mm of foveal center); seven eyes (11.86%) had peri-central fixation location (25% << 50% within 0.5 mm); and seven eyes (11.86%) had eccentric (<25% of fixation point within 0.5 mm) fixation location. We measured macular sensitivity and corresponding thickness in 1,708 loci of 61 study eyes. Macular sensitivity increased by 0.02 dB (95% confidence interval, 0.00, 0.06) per 1 μm increase in the thickness for the thickness values ≤280 μm. Macular sensitivity decreased by 0.04 dB (95% CI, -0.08, -0.01) per 1 μm increase in the thickness for the thickness values >280 μm. Conclusions: Perimetry quantification of macular sensitivity and retinal thickness, in association with other factors, may offer novel information regarding the impact of UME on retinal function.

AB - Purpose: This study aims to investigate the relationship between macular sensitivity and thickness in eyes with uveitic macular edema (UME). Design: This study is a prospective observational case series. Methods: The setting for this study was clinical practice. The study included 59 (28 with UME, 31 without UME) eyes of 26 patients with uveitis and 19 eyes of 10 normal subjects. The procedure followed was fundus-related perimetry and retinal thickness map with an automated fundus perimetry/tomography system. Main outcome measures included quantification of macular sensitivity, fixation pattern, and relationship between macular sensitivity and thickness. Results: Fixation stability revealed that 56 eyes (93.44%) had stable fixation (>75% within the central 2° of point of fixation); three eyes (6.56%) were relatively unstable (<75% of fixation points located within 2°, >75% located within 4°); and no eye had unstable fixation (<75% of fixation points located within 4°). Evaluation of fixation location revealed that 45 eyes (76.27%) had central fixation location (>50% of fixation point within 0.5 mm of foveal center); seven eyes (11.86%) had peri-central fixation location (25% << 50% within 0.5 mm); and seven eyes (11.86%) had eccentric (<25% of fixation point within 0.5 mm) fixation location. We measured macular sensitivity and corresponding thickness in 1,708 loci of 61 study eyes. Macular sensitivity increased by 0.02 dB (95% confidence interval, 0.00, 0.06) per 1 μm increase in the thickness for the thickness values ≤280 μm. Macular sensitivity decreased by 0.04 dB (95% CI, -0.08, -0.01) per 1 μm increase in the thickness for the thickness values >280 μm. Conclusions: Perimetry quantification of macular sensitivity and retinal thickness, in association with other factors, may offer novel information regarding the impact of UME on retinal function.

KW - Microperimetry

KW - Retinal thickness

KW - Uveitic macular edema

KW - Uveitis

UR - http://www.scopus.com/inward/record.url?scp=84878531056&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84878531056&partnerID=8YFLogxK

U2 - 10.1007/s12348-011-0052-8

DO - 10.1007/s12348-011-0052-8

M3 - Article

VL - 2

SP - 65

EP - 73

JO - Journal of Ophthalmic Inflammation and Infection

JF - Journal of Ophthalmic Inflammation and Infection

SN - 1869-5760

IS - 2

ER -