Macrophages, microglia and dendritic cell function

James Hilaire, Howard Eliot Gendelman

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Mononuclear phagocytes (MP; monocytes, macrophages, microglia and dendritic cells) are joined together based on common function and phenotypic properties. In regards to phagocytoic, interacellular killing, secretory, antigen presentation and mobility properties differentiating the cell types can be difficult. Ontogeny, locale and modest phenotype differences underlie differences. Similarities abound in innate immunity and protection of a steady-state homeostatic environment and engaging inflammatory responses that direct surveillance and clearance responses. A clear benefit of spanning tissue origins and species differences underlies the importance of these cells that serve as the first line of immune defense.

Original languageEnglish (US)
Title of host publicationNeuroimmune Pharmacology
PublisherSpringer International Publishing
Pages153-166
Number of pages14
ISBN (Electronic)9783319440224
ISBN (Print)9783319440200
DOIs
StatePublished - Jan 1 2016

Fingerprint

Microglia
Dendritic Cells
Macrophages
Antigen Presentation
Phagocytes
Innate Immunity
Monocytes
Phenotype

Keywords

  • Dendritic cells
  • Macrophages
  • Major histocompatibility
  • Microglia
  • Mononuclear phagocytes
  • Multiple sclerosis
  • Neurodegeneration
  • Neuroprotection
  • Pathogen-associated patterns
  • Progenitor cells
  • Reactive oxygen species
  • Toll-like receptors

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)
  • Neuroscience(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Hilaire, J., & Gendelman, H. E. (2016). Macrophages, microglia and dendritic cell function. In Neuroimmune Pharmacology (pp. 153-166). Springer International Publishing. https://doi.org/10.1007/978-3-319-44022-4_12

Macrophages, microglia and dendritic cell function. / Hilaire, James; Gendelman, Howard Eliot.

Neuroimmune Pharmacology. Springer International Publishing, 2016. p. 153-166.

Research output: Chapter in Book/Report/Conference proceedingChapter

Hilaire, J & Gendelman, HE 2016, Macrophages, microglia and dendritic cell function. in Neuroimmune Pharmacology. Springer International Publishing, pp. 153-166. https://doi.org/10.1007/978-3-319-44022-4_12
Hilaire J, Gendelman HE. Macrophages, microglia and dendritic cell function. In Neuroimmune Pharmacology. Springer International Publishing. 2016. p. 153-166 https://doi.org/10.1007/978-3-319-44022-4_12
Hilaire, James ; Gendelman, Howard Eliot. / Macrophages, microglia and dendritic cell function. Neuroimmune Pharmacology. Springer International Publishing, 2016. pp. 153-166
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