Macrophage roles following myocardial infarction

Jessica M. Lambert, Elizabeth F. Lopez, Merry L Lindsey

Research output: Contribution to journalReview article

199 Citations (Scopus)

Abstract

Following myocardial infarction (MI), circulating blood monocytes respond to chemotactic factors, migrate into the infarcted myocardium, and differentiate into macrophages. At the injury site, macrophages remove necrotic cardiac myocytes and apoptotic neutrophils; secrete cytokines, chemokines, and growth factors; and modulate phases of the angiogenic response. As such, the macrophage is a primary responder cell type that is involved in the regulation of post-MI wound healing at multiple levels. This review summarizes what is currently known about macrophage functions post-MI and borrows literature from other injury and inflammatory models to speculate on additional roles. Basic science and clinical avenues that remain to be explored are also discussed.

Original languageEnglish (US)
Pages (from-to)147-158
Number of pages12
JournalInternational Journal of Cardiology
Volume130
Issue number2
DOIs
StatePublished - Nov 12 2008

Fingerprint

Macrophages
Myocardial Infarction
Chemotactic Factors
Wounds and Injuries
Chemokines
Cardiac Myocytes
Wound Healing
Monocytes
Intercellular Signaling Peptides and Proteins
Myocardium
Neutrophils
Cytokines

Keywords

  • Angiogenesis
  • Fibrosis
  • Left ventricular remodeling
  • Macrophage
  • Matrix metalloproteinases
  • Myocardial infarction

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Macrophage roles following myocardial infarction. / Lambert, Jessica M.; Lopez, Elizabeth F.; Lindsey, Merry L.

In: International Journal of Cardiology, Vol. 130, No. 2, 12.11.2008, p. 147-158.

Research output: Contribution to journalReview article

Lambert, Jessica M. ; Lopez, Elizabeth F. ; Lindsey, Merry L. / Macrophage roles following myocardial infarction. In: International Journal of Cardiology. 2008 ; Vol. 130, No. 2. pp. 147-158.
@article{80dcce2485c94adfb7629476c722a98d,
title = "Macrophage roles following myocardial infarction",
abstract = "Following myocardial infarction (MI), circulating blood monocytes respond to chemotactic factors, migrate into the infarcted myocardium, and differentiate into macrophages. At the injury site, macrophages remove necrotic cardiac myocytes and apoptotic neutrophils; secrete cytokines, chemokines, and growth factors; and modulate phases of the angiogenic response. As such, the macrophage is a primary responder cell type that is involved in the regulation of post-MI wound healing at multiple levels. This review summarizes what is currently known about macrophage functions post-MI and borrows literature from other injury and inflammatory models to speculate on additional roles. Basic science and clinical avenues that remain to be explored are also discussed.",
keywords = "Angiogenesis, Fibrosis, Left ventricular remodeling, Macrophage, Matrix metalloproteinases, Myocardial infarction",
author = "Lambert, {Jessica M.} and Lopez, {Elizabeth F.} and Lindsey, {Merry L}",
year = "2008",
month = "11",
day = "12",
doi = "10.1016/j.ijcard.2008.04.059",
language = "English (US)",
volume = "130",
pages = "147--158",
journal = "International Journal of Cardiology",
issn = "0167-5273",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

TY - JOUR

T1 - Macrophage roles following myocardial infarction

AU - Lambert, Jessica M.

AU - Lopez, Elizabeth F.

AU - Lindsey, Merry L

PY - 2008/11/12

Y1 - 2008/11/12

N2 - Following myocardial infarction (MI), circulating blood monocytes respond to chemotactic factors, migrate into the infarcted myocardium, and differentiate into macrophages. At the injury site, macrophages remove necrotic cardiac myocytes and apoptotic neutrophils; secrete cytokines, chemokines, and growth factors; and modulate phases of the angiogenic response. As such, the macrophage is a primary responder cell type that is involved in the regulation of post-MI wound healing at multiple levels. This review summarizes what is currently known about macrophage functions post-MI and borrows literature from other injury and inflammatory models to speculate on additional roles. Basic science and clinical avenues that remain to be explored are also discussed.

AB - Following myocardial infarction (MI), circulating blood monocytes respond to chemotactic factors, migrate into the infarcted myocardium, and differentiate into macrophages. At the injury site, macrophages remove necrotic cardiac myocytes and apoptotic neutrophils; secrete cytokines, chemokines, and growth factors; and modulate phases of the angiogenic response. As such, the macrophage is a primary responder cell type that is involved in the regulation of post-MI wound healing at multiple levels. This review summarizes what is currently known about macrophage functions post-MI and borrows literature from other injury and inflammatory models to speculate on additional roles. Basic science and clinical avenues that remain to be explored are also discussed.

KW - Angiogenesis

KW - Fibrosis

KW - Left ventricular remodeling

KW - Macrophage

KW - Matrix metalloproteinases

KW - Myocardial infarction

UR - http://www.scopus.com/inward/record.url?scp=54949106928&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=54949106928&partnerID=8YFLogxK

U2 - 10.1016/j.ijcard.2008.04.059

DO - 10.1016/j.ijcard.2008.04.059

M3 - Review article

VL - 130

SP - 147

EP - 158

JO - International Journal of Cardiology

JF - International Journal of Cardiology

SN - 0167-5273

IS - 2

ER -