Macrophage-derived simian immunodeficiency virus exhibits enhanced infectivity by comparison with T-cell-derived virus

Peter J. Gaskill, Michelle Zandonatti, Tim Gilmartin, Steven R. Head, Howard S. Fox

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) infect and productively replicate in macrophages and T lymphocytes. Here, we show that SIV virions derived from macrophages have higher levels of infectivity than those derived from T cells. The lower infectivity of T-cell-derived viruses is influenced by the quantity or type of mannose residues on the virion. Our results demonstrate that the cellular origin of a virus is a major factor in viral infectivity. Cell-type-specific factors in viral infectivity, and organ-specific or disease stage-specific differences in cellular derivation of virions, can be critical in the pathogenesis of HIV and AIDS.

Original languageEnglish (US)
Pages (from-to)1615-1621
Number of pages7
JournalJournal of virology
Volume82
Issue number3
DOIs
StatePublished - Feb 1 2008

Fingerprint

Simian immunodeficiency virus
Simian Immunodeficiency Virus
Virion
macrophages
pathogenicity
T-lymphocytes
Macrophages
virion
Viruses
T-Lymphocytes
viruses
Human immunodeficiency virus
HIV
Mannose
Acquired Immunodeficiency Syndrome
mannose
pathogenesis
cells

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

Cite this

Macrophage-derived simian immunodeficiency virus exhibits enhanced infectivity by comparison with T-cell-derived virus. / Gaskill, Peter J.; Zandonatti, Michelle; Gilmartin, Tim; Head, Steven R.; Fox, Howard S.

In: Journal of virology, Vol. 82, No. 3, 01.02.2008, p. 1615-1621.

Research output: Contribution to journalArticle

Gaskill, Peter J. ; Zandonatti, Michelle ; Gilmartin, Tim ; Head, Steven R. ; Fox, Howard S. / Macrophage-derived simian immunodeficiency virus exhibits enhanced infectivity by comparison with T-cell-derived virus. In: Journal of virology. 2008 ; Vol. 82, No. 3. pp. 1615-1621.
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