M6P/IGF2R imprinting evolution in mammals

J. Keith Killian, James C. Byrd, James V. Jirtle, Barry L. Munday, Michael K. Stoskopf, Richard G MacDonald, Randy L. Jirtle

Research output: Contribution to journalArticle

206 Citations (Scopus)

Abstract

Imprinted gene identification in animals has been limited to eutherian mammals, suggesting a significant role for intrauterine fetal development in the evolution of imprinting. We report herein that M6P/IGF2R is not imprinted in monotremes and does not encode for a receptor that binds IGF2. In contrast, M6P/IGF2R is imprinted in a didelphid marsupial, the opossum, but it strikingly lacks the differentially methylated CpG island in intron 2 postulated to be involved in imprint control. Thus, invasive placentation and gestational fetal growth are not required for imprinted genes to evolve. Unless there was convergent evolution of M6P/IGF2R imprinting and receptor IGF2 binding in marsupials and eutherians, our results also demonstrate that these two functions evolved in a mammalian clade exclusive of monotremes.

Original languageEnglish (US)
Pages (from-to)707-716
Number of pages10
JournalMolecular Cell
Volume5
Issue number4
DOIs
StatePublished - Jan 1 2000

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Marsupialia
Fetal Development
Mammals
Opossums
Placentation
CpG Islands
Introns
Genes

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Cite this

Killian, J. K., Byrd, J. C., Jirtle, J. V., Munday, B. L., Stoskopf, M. K., MacDonald, R. G., & Jirtle, R. L. (2000). M6P/IGF2R imprinting evolution in mammals. Molecular Cell, 5(4), 707-716. https://doi.org/10.1016/S1097-2765(00)80249-X

M6P/IGF2R imprinting evolution in mammals. / Killian, J. Keith; Byrd, James C.; Jirtle, James V.; Munday, Barry L.; Stoskopf, Michael K.; MacDonald, Richard G; Jirtle, Randy L.

In: Molecular Cell, Vol. 5, No. 4, 01.01.2000, p. 707-716.

Research output: Contribution to journalArticle

Killian, JK, Byrd, JC, Jirtle, JV, Munday, BL, Stoskopf, MK, MacDonald, RG & Jirtle, RL 2000, 'M6P/IGF2R imprinting evolution in mammals', Molecular Cell, vol. 5, no. 4, pp. 707-716. https://doi.org/10.1016/S1097-2765(00)80249-X
Killian JK, Byrd JC, Jirtle JV, Munday BL, Stoskopf MK, MacDonald RG et al. M6P/IGF2R imprinting evolution in mammals. Molecular Cell. 2000 Jan 1;5(4):707-716. https://doi.org/10.1016/S1097-2765(00)80249-X
Killian, J. Keith ; Byrd, James C. ; Jirtle, James V. ; Munday, Barry L. ; Stoskopf, Michael K. ; MacDonald, Richard G ; Jirtle, Randy L. / M6P/IGF2R imprinting evolution in mammals. In: Molecular Cell. 2000 ; Vol. 5, No. 4. pp. 707-716.
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