M6P/IGF2R imprinting evolution in mammals

J. Keith Killian, James C. Byrd, James V. Jirtle, Barry L. Munday, Michael K. Stoskopf, Richard G. MacDonald, Randy L. Jirtle

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Abstract

Imprinted gene identification in animals has been limited to eutherian mammals, suggesting a significant role for intrauterine fetal development in the evolution of imprinting. We report herein that M6P/IGF2R is not imprinted in monotremes and does not encode for a receptor that binds IGF2. In contrast, M6P/IGF2R is imprinted in a didelphid marsupial, the opossum, but it strikingly lacks the differentially methylated CpG island in intron 2 postulated to be involved in imprint control. Thus, invasive placentation and gestational fetal growth are not required for imprinted genes to evolve. Unless there was convergent evolution of M6P/IGF2R imprinting and receptor IGF2 binding in marsupials and eutherians, our results also demonstrate that these two functions evolved in a mammalian clade exclusive of monotremes.

Original languageEnglish (US)
Pages (from-to)707-716
Number of pages10
JournalMolecular Cell
Volume5
Issue number4
DOIs
StatePublished - Jan 1 2000

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ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Cite this

Killian, J. K., Byrd, J. C., Jirtle, J. V., Munday, B. L., Stoskopf, M. K., MacDonald, R. G., & Jirtle, R. L. (2000). M6P/IGF2R imprinting evolution in mammals. Molecular Cell, 5(4), 707-716. https://doi.org/10.1016/S1097-2765(00)80249-X