Lysosomal storage disorders: pathology within the lysosome and beyond

Research output: Contribution to journalEditorial

2 Citations (Scopus)

Abstract

This Preface introduces the articles of the special issue on “Lysosomal Storage Disorders” in which several recognized experts provide an overview of this research field. Lysosomes were first described in the 1950s and recognized for their role in substrate degradation and recycling. Because lysosomes impact numerous fundamental homeostatic processes, research on lysosomal storage disorders (LSDs) is crucial to advance our understanding of this intriguing organelle. This Special Issue highlights some of the LSDs that impact the central nervous system (CNS) as well as comprehensive overviews of lysosomal biology, CNS metabolism, and sphingolipid biosynthesis and turnover, all of which are critical toward our understanding of normal lysosomal function and how this is perturbed in the context of LSDs. (Figure presented.). This is the Preface for the special issue “Lysosomal Storage Disorders”. Cover Image for this issue: doi: 10.1111/jnc.14496.

Original languageEnglish (US)
Pages (from-to)568-572
Number of pages5
JournalJournal of Neurochemistry
Volume148
Issue number5
DOIs
StatePublished - Mar 2019

Fingerprint

Neurology
Pathology
Lysosomes
Sphingolipids
Central Nervous System Diseases
Biosynthesis
Recycling
Research
Metabolism
Organelles
Central Nervous System
Degradation
Substrates

Keywords

  • Lysosomal storage disorders
  • juvenile Batten disease
  • lysosome
  • mucolipidosis type IV
  • mucopolysaccharidoses
  • transcription factor EB (TFEB)

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

Cite this

Lysosomal storage disorders : pathology within the lysosome and beyond. / Kielian, Tammy.

In: Journal of Neurochemistry, Vol. 148, No. 5, 03.2019, p. 568-572.

Research output: Contribution to journalEditorial

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