Lysosomal enzyme in Mastomys natalensis during Dipetalonema viteae infection

A. K. Srivastava, Dhirendra P Singh, R. K. Chatterjee, S. Ghatak

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Activities of certain acid hydrolases (viz. acid phosphatase, β-glucosidase, β-galactosidase, N-acetyl-β-D-glucosaminidase and cathepsin) of post mitochondrial fraction of liver and spleen were studied during the course of Dipetalonema viteae in Mastomys natalensis. The values are significantly higher from prepatent to patent phase of infection as compared with normal animals. However, a decrease in the activity of hepatic acid phosphatase and N-acetyl-β-D-glucosaminidase was noticed in latent phase of infection while a several fold increase in the activity of these enzymes was observed in splenic tissue when there were no detectable microfilariae (mf) in peripheral circulation. The results suggest that lysosomal acid hydrolases which constitute an important component of resistance may be activated by mf products through the sensitized cells of RE system.

Original languageEnglish (US)
Pages (from-to)174-176
Number of pages3
JournalTropenmedizin und Parasitologie
Volume34
Issue number3
StatePublished - Jan 1 1983

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Dipetalonema Infections
Murinae
Hexosaminidases
Microfilariae
Hydrolases
Acid Phosphatase
Dipetalonema
Galactosidases
Glucosidases
Cathepsin D
Acids
Liver
Enzymes
Infection
Spleen

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

Cite this

Lysosomal enzyme in Mastomys natalensis during Dipetalonema viteae infection. / Srivastava, A. K.; Singh, Dhirendra P; Chatterjee, R. K.; Ghatak, S.

In: Tropenmedizin und Parasitologie, Vol. 34, No. 3, 01.01.1983, p. 174-176.

Research output: Contribution to journalArticle

Srivastava, AK, Singh, DP, Chatterjee, RK & Ghatak, S 1983, 'Lysosomal enzyme in Mastomys natalensis during Dipetalonema viteae infection', Tropenmedizin und Parasitologie, vol. 34, no. 3, pp. 174-176.
Srivastava, A. K. ; Singh, Dhirendra P ; Chatterjee, R. K. ; Ghatak, S. / Lysosomal enzyme in Mastomys natalensis during Dipetalonema viteae infection. In: Tropenmedizin und Parasitologie. 1983 ; Vol. 34, No. 3. pp. 174-176.
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