Lymphoepithelioma in childhood

Terry Pick, Harold M. Maurer, Nancy B. McWilliams

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Nine black children with lymphoepithelioma, a rare malignancy of childhood, are the subject of this report. Unique clinical features included tender cervical lymphadenopathy with torticollis, trismus, epistaxis, and change in voice quality. A nasopharyngeal mass was demonstrable in seven children on careful examination, but none was resectable. Treatment with radiation alone or radiation plus cyclophosphamide resulted in complete tumor regression in eight of the nine children. Local recurrence or distant metastases occurred in four within 10 months, two of whom responded to additional radiation plus cyclophosphamide or adriamycin. At present, four children are alive without disease for periods of seven to 78 months, two are alive for seven to 53 months and are in remission from recurrent disease, and three have died with distant metastases. Freedom from disease for one year was associated with a favorable prognosis. Adjuvant chemotherapy appears warranted in view of the high incidence of local recurrence and distant metastases.

Original languageEnglish (US)
Pages (from-to)96-100
Number of pages5
JournalThe Journal of Pediatrics
Volume84
Issue number1
DOIs
StatePublished - Jan 1974

Fingerprint

Radiation
Neoplasm Metastasis
Cyclophosphamide
Trismus
Voice Quality
Recurrence
Torticollis
Epistaxis
Adjuvant Chemotherapy
Doxorubicin
Neoplasms
Incidence
Therapeutics
Lymphadenopathy

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Pick, T., Maurer, H. M., & McWilliams, N. B. (1974). Lymphoepithelioma in childhood. The Journal of Pediatrics, 84(1), 96-100. https://doi.org/10.1016/S0022-3476(74)80560-3

Lymphoepithelioma in childhood. / Pick, Terry; Maurer, Harold M.; McWilliams, Nancy B.

In: The Journal of Pediatrics, Vol. 84, No. 1, 01.1974, p. 96-100.

Research output: Contribution to journalArticle

Pick, T, Maurer, HM & McWilliams, NB 1974, 'Lymphoepithelioma in childhood', The Journal of Pediatrics, vol. 84, no. 1, pp. 96-100. https://doi.org/10.1016/S0022-3476(74)80560-3
Pick, Terry ; Maurer, Harold M. ; McWilliams, Nancy B. / Lymphoepithelioma in childhood. In: The Journal of Pediatrics. 1974 ; Vol. 84, No. 1. pp. 96-100.
@article{324fc45b8f2e4efaba8cf6900d1d0e76,
title = "Lymphoepithelioma in childhood",
abstract = "Nine black children with lymphoepithelioma, a rare malignancy of childhood, are the subject of this report. Unique clinical features included tender cervical lymphadenopathy with torticollis, trismus, epistaxis, and change in voice quality. A nasopharyngeal mass was demonstrable in seven children on careful examination, but none was resectable. Treatment with radiation alone or radiation plus cyclophosphamide resulted in complete tumor regression in eight of the nine children. Local recurrence or distant metastases occurred in four within 10 months, two of whom responded to additional radiation plus cyclophosphamide or adriamycin. At present, four children are alive without disease for periods of seven to 78 months, two are alive for seven to 53 months and are in remission from recurrent disease, and three have died with distant metastases. Freedom from disease for one year was associated with a favorable prognosis. Adjuvant chemotherapy appears warranted in view of the high incidence of local recurrence and distant metastases.",
author = "Terry Pick and Maurer, {Harold M.} and McWilliams, {Nancy B.}",
year = "1974",
month = "1",
doi = "10.1016/S0022-3476(74)80560-3",
language = "English (US)",
volume = "84",
pages = "96--100",
journal = "Journal of Pediatrics",
issn = "0022-3476",
publisher = "Mosby Inc.",
number = "1",

}

TY - JOUR

T1 - Lymphoepithelioma in childhood

AU - Pick, Terry

AU - Maurer, Harold M.

AU - McWilliams, Nancy B.

PY - 1974/1

Y1 - 1974/1

N2 - Nine black children with lymphoepithelioma, a rare malignancy of childhood, are the subject of this report. Unique clinical features included tender cervical lymphadenopathy with torticollis, trismus, epistaxis, and change in voice quality. A nasopharyngeal mass was demonstrable in seven children on careful examination, but none was resectable. Treatment with radiation alone or radiation plus cyclophosphamide resulted in complete tumor regression in eight of the nine children. Local recurrence or distant metastases occurred in four within 10 months, two of whom responded to additional radiation plus cyclophosphamide or adriamycin. At present, four children are alive without disease for periods of seven to 78 months, two are alive for seven to 53 months and are in remission from recurrent disease, and three have died with distant metastases. Freedom from disease for one year was associated with a favorable prognosis. Adjuvant chemotherapy appears warranted in view of the high incidence of local recurrence and distant metastases.

AB - Nine black children with lymphoepithelioma, a rare malignancy of childhood, are the subject of this report. Unique clinical features included tender cervical lymphadenopathy with torticollis, trismus, epistaxis, and change in voice quality. A nasopharyngeal mass was demonstrable in seven children on careful examination, but none was resectable. Treatment with radiation alone or radiation plus cyclophosphamide resulted in complete tumor regression in eight of the nine children. Local recurrence or distant metastases occurred in four within 10 months, two of whom responded to additional radiation plus cyclophosphamide or adriamycin. At present, four children are alive without disease for periods of seven to 78 months, two are alive for seven to 53 months and are in remission from recurrent disease, and three have died with distant metastases. Freedom from disease for one year was associated with a favorable prognosis. Adjuvant chemotherapy appears warranted in view of the high incidence of local recurrence and distant metastases.

UR - http://www.scopus.com/inward/record.url?scp=0015972072&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0015972072&partnerID=8YFLogxK

U2 - 10.1016/S0022-3476(74)80560-3

DO - 10.1016/S0022-3476(74)80560-3

M3 - Article

C2 - 12119964

AN - SCOPUS:0015972072

VL - 84

SP - 96

EP - 100

JO - Journal of Pediatrics

JF - Journal of Pediatrics

SN - 0022-3476

IS - 1

ER -