Lymphocytic (microscopic) colitis - Clinicopathologic study of 18 patients and comparison to collagenous colitis

Francis M. Giardiello, Audrey J. Lazenby, Theodore M. Bayless, Edward J. Levine, Wilma B. Bias, Paul W. Ladenson, David F. Hutcheon, Nancy L. Derevjanik, John H. Yardley

Research output: Contribution to journalArticle

138 Citations (Scopus)

Abstract

Lymphocytic colitis, formerly called microscopic colitis, is a clinicopathologic syndrome with chronic watery diarrhea and diffuse mucosal inflammatory changes with prominent intraepithelial lymphocytes. The 18 lymphocytic colitis patients studied presented with chronic watery diarrhea at a mean age of 53.8±17 years (±1 SD). Roentgenographic, endoscopic, and culture data were not diagnostic. In patients tested, there was a high prevalence of arthritis (82%) and autoantibodies (50%) but no increase in frequency of histocompatibility antigens associated with well-defined autoimmune disease (DR3, B8). Lymphocytic colitis patients were compared to 21 patients with collagenous colitis. Similarities included age, symptomatology, and nondiagnostic radiographic and endoscopic studies. However, the sex distribution was statistically different, with an equal male-to-female ratio in lymphocytic colitis and female predominance (80%) in collagenous colitis. Other differences included dissimilar histocompatibility phenotypes and collagen band on biopsies of collagenous but not lymphocytic colitis. These findings suggest that lymphocytic and collagenous colitis may be related yet distinct disorders.

Original languageEnglish (US)
Pages (from-to)1730-1738
Number of pages9
JournalDigestive Diseases and Sciences
Volume34
Issue number11
DOIs
StatePublished - Nov 1 1989

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Lymphocytic Colitis
Microscopic Colitis
Collagenous Colitis
Diarrhea
Sex Distribution
Histocompatibility Antigens
Histocompatibility
Autoantibodies
Autoimmune Diseases
Arthritis
Collagen
Lymphocytes
Phenotype
Biopsy

Keywords

  • autoimmune
  • collagenous colitis
  • lymphocytic colitis
  • microscopic colitis

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

Cite this

Giardiello, F. M., Lazenby, A. J., Bayless, T. M., Levine, E. J., Bias, W. B., Ladenson, P. W., ... Yardley, J. H. (1989). Lymphocytic (microscopic) colitis - Clinicopathologic study of 18 patients and comparison to collagenous colitis. Digestive Diseases and Sciences, 34(11), 1730-1738. https://doi.org/10.1007/BF01540051

Lymphocytic (microscopic) colitis - Clinicopathologic study of 18 patients and comparison to collagenous colitis. / Giardiello, Francis M.; Lazenby, Audrey J.; Bayless, Theodore M.; Levine, Edward J.; Bias, Wilma B.; Ladenson, Paul W.; Hutcheon, David F.; Derevjanik, Nancy L.; Yardley, John H.

In: Digestive Diseases and Sciences, Vol. 34, No. 11, 01.11.1989, p. 1730-1738.

Research output: Contribution to journalArticle

Giardiello, FM, Lazenby, AJ, Bayless, TM, Levine, EJ, Bias, WB, Ladenson, PW, Hutcheon, DF, Derevjanik, NL & Yardley, JH 1989, 'Lymphocytic (microscopic) colitis - Clinicopathologic study of 18 patients and comparison to collagenous colitis', Digestive Diseases and Sciences, vol. 34, no. 11, pp. 1730-1738. https://doi.org/10.1007/BF01540051
Giardiello, Francis M. ; Lazenby, Audrey J. ; Bayless, Theodore M. ; Levine, Edward J. ; Bias, Wilma B. ; Ladenson, Paul W. ; Hutcheon, David F. ; Derevjanik, Nancy L. ; Yardley, John H. / Lymphocytic (microscopic) colitis - Clinicopathologic study of 18 patients and comparison to collagenous colitis. In: Digestive Diseases and Sciences. 1989 ; Vol. 34, No. 11. pp. 1730-1738.
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