Lymphocytes bearing receptors for both sheep erythrocytes and complement in patients with neoplastic and non-neoplastic diseases

Kazimiera J. Gajl-Peczalska, Sandra Chartrand, Clara D. Bloomfield, Jean Corte, Peter Felix Coccia, Mark E. Nesbit, John H. Kersey

Research output: Contribution to journalArticle

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Abstract

To identify lymphoid cells bearing receptors for both sheep erythrocytes (sE) and complement (C′), a combined rosette assay was developed using uncoated sE and chicken erythrocytes coated with antibody and complement (cEAC′). Cells with both receptors were present in low percentages in the blood of normal individuals. Tissues and/or blood from 543 patients with various diseases were studied using the combined rosette assay. Large numbers of malignant cells were found to carry receptors for both C′ and sE in four patients with lymphoproliferative malignancies. Two were children with lymphoma who had mediastinal masses. The other two were adults with chronic lymphocytic leukemia; their cells also carried surface immunoglobulin and Fc receptors. In these four patients double or multiple receptor lymphocytes may represent a clonal proliferation of subsets of lymphocytes present in small numbers under normal conditions. An increase in double receptor lymphocytes was rare in the non-neoplastic conditions studied and seen only in children. Double receptor lymphocytes may represent an immature or "stem" cell lymphocyte subset.

Original languageEnglish (US)
Pages (from-to)292-299
Number of pages8
JournalClinical Immunology and Immunopathology
Volume8
Issue number2
DOIs
StatePublished - Jan 1 1977

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Sheep
Erythrocytes
Lymphocytes
Lymphocyte Subsets
B-Cell Antigen Receptors
Fc Receptors
B-Cell Chronic Lymphocytic Leukemia
Chickens
Lymphoma
Stem Cells
Cell Count
Antibodies
Neoplasms

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pathology and Forensic Medicine
  • Immunology

Cite this

Gajl-Peczalska, K. J., Chartrand, S., Bloomfield, C. D., Corte, J., Coccia, P. F., Nesbit, M. E., & Kersey, J. H. (1977). Lymphocytes bearing receptors for both sheep erythrocytes and complement in patients with neoplastic and non-neoplastic diseases. Clinical Immunology and Immunopathology, 8(2), 292-299. https://doi.org/10.1016/0090-1229(77)90119-2

Lymphocytes bearing receptors for both sheep erythrocytes and complement in patients with neoplastic and non-neoplastic diseases. / Gajl-Peczalska, Kazimiera J.; Chartrand, Sandra; Bloomfield, Clara D.; Corte, Jean; Coccia, Peter Felix; Nesbit, Mark E.; Kersey, John H.

In: Clinical Immunology and Immunopathology, Vol. 8, No. 2, 01.01.1977, p. 292-299.

Research output: Contribution to journalArticle

Gajl-Peczalska, Kazimiera J. ; Chartrand, Sandra ; Bloomfield, Clara D. ; Corte, Jean ; Coccia, Peter Felix ; Nesbit, Mark E. ; Kersey, John H. / Lymphocytes bearing receptors for both sheep erythrocytes and complement in patients with neoplastic and non-neoplastic diseases. In: Clinical Immunology and Immunopathology. 1977 ; Vol. 8, No. 2. pp. 292-299.
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