Lymphocyte proliferation in immune-mediated diseases

Shrimati Datta, Nora E Sarvetnick

Research output: Contribution to journalReview article

61 Scopus citations

Abstract

Defects in T cell homeostatic mechanisms can result in T cell lymphopenia, defined as decreased numbers of lymphocytes. Lymphopenia results in homeostatic proliferation in order to maintain T cell homeostasis. It has been proposed that homeostatic proliferation can expand the pool of autoreactive T cells that promote autoimmunity, and indeed recent studies have further substantiated this observation in both animal models and humans. Conversely, homeostatic proliferation can promote tumor immunity by allowing tumor-specific T cells to accumulate. In this review, we discuss how the outcome of homeostatic proliferation can function both in a deleterious manner in autoimmunity and a beneficial way in tumor immunity. We also discuss the roles of various cytokines and T regulatory cells that control homeostatic proliferation.

Original languageEnglish (US)
Pages (from-to)430-438
Number of pages9
JournalTrends in Immunology
Volume30
Issue number9
DOIs
Publication statusPublished - Sep 1 2009

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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