Lymphocyte fluorescent profiles (LFP): A possible screening technique in neoplasia

L. A. Love, N. F. Metcalf, W. K. Metcalf, John G Sharp

Research output: Contribution to journalArticle

Abstract

A technique involving fluorescent protein staining and microfluorometry has been developed for measuring the lymphocyte fluorescent profile (LFP) of peripheral blood lymphocytes. In contrast to normal humans who display a regular bell-shaped curve, the profile from patients with cancer is irregular, showing a bimodal distribution of fluorescence, with a significant population of cells fluorescing at a higher relative intensity. It is suggested that this elevation in protein concentration is due to an immune response to the presence of a neoplasm, and thus this technique may prove to be a useful indicator of malignancy.

Original languageEnglish (US)
Pages (from-to)357-364
Number of pages8
JournalCancer Letters
Volume6
Issue number6
DOIs
Publication statusPublished - May 1979

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ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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