Lymphatic malformations: Current cellular and clinical investigations

Jonathan A. Perkins, Scott C. Manning, Richard M. Tempero, Michael J. Cunningham, Joseph L. Edmonds, Fredric A. Hoffer, Mark A. Egbert

Research output: Contribution to journalArticle

65 Scopus citations


Objective: Summarize current knowledge of lymphatic malformation development, biology, and clinical outcome measures. Methods: Panel presentation of lymphatic malformation biology and measurement of head and neck malformation treatment outcomes. Results: Characterization of lymphatic malformation endothelial and stromal cells may lead to biologically based treatment. Traditionally, lymphatic malformation treatment outcomes have been measured according to reduction of malformation size. Currently, methods to measure functional outcomes following lymphatic malformation treatment are lacking. This is particularly apparent when the malformation directly involves the upper aerodigestive tract. Conclusions: The etiology and pathogenesis of head and neck lymphatic malformations are poorly understood, but understanding is improving through ongoing investigation. Reduction of lymphatic malformation size is generally possible, but further work is necessary to optimize methods for measuring therapeutic outcomes in problematic areas.

Original languageEnglish (US)
Pages (from-to)789-794
Number of pages6
JournalOtolaryngology - Head and Neck Surgery
Issue number6
StatePublished - Jun 1 2010


ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology

Cite this

Perkins, J. A., Manning, S. C., Tempero, R. M., Cunningham, M. J., Edmonds, J. L., Hoffer, F. A., & Egbert, M. A. (2010). Lymphatic malformations: Current cellular and clinical investigations. Otolaryngology - Head and Neck Surgery, 142(6), 789-794.