Lung to head ratio in infants with congenital diaphragmatic hernia does not predict long term pulmonary hypertension

Alejandro V. Garcia, Abbey L Fingeret, Arul S. Thirumoorthi, Eunice Hahn, Matthew J. Leskowitz, Gudrun Aspelund, Usha S. Krishnan, Charles J.H. Stolar

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Purpose: Lung-to-head ratio (LHR) has been used for antenatal evaluation of infants with congenital diaphragmatic hernia (CDH). We hypothesized that LHR was predictive of acute and chronic pulmonary hypertension in infants with CDH. Methods: Echocardiograms on all inborn infants with CDH (December 2001-March 2011) were reviewed. Echocardiograms at 1 and 3 months post-repair and most recent follow-up were assessed for presence of pulmonary hypertension (PAH). LHR, gestational age, birth weight, extracorporeal membrane oxygenation (ECMO), and death rate were obtained. Bivariate and multivariate analyses were performed. Results: 106 infants with CDH had LHR obtained at median 28 weeks gestation (median LHR = 1.25 [range 0.4-5.3]). Median follow-up was 26.6 months (range 4.6-97.5). The long-term incidence of pulmonary hypertension was 16%. LHR was significantly associated with pulmonary hypertension at one month (p = 0.0001) but not at 3 months (p = 0.22) or long-term (p = 0.54). LHR was predictive of ECMO use (p = 0.01) and death (p = 0.001). Conclusions: The overall incidence of PAH in infants with CDH decreases over time. Prenatal LHR predicts PAH at one month but not long-term in infants with CDH. The ability for LHR to predict PAH at one month but not long term may suggest remodeling of the pulmonary vasculature over time.

Original languageEnglish (US)
Pages (from-to)154-157
Number of pages4
JournalJournal of Pediatric Surgery
Volume48
Issue number1
DOIs
StatePublished - Jan 1 2013

Fingerprint

Pulmonary Hypertension
Head
Lung
Extracorporeal Membrane Oxygenation
Congenital Diaphragmatic Hernias
Incidence
Birth Weight
Gestational Age
Multivariate Analysis
Pregnancy
Mortality

Keywords

  • Congenital diaphragmatic hernia
  • ECMO
  • Lung-to-head ratio
  • Pulmonary hypertension

ASJC Scopus subject areas

  • Surgery
  • Pediatrics, Perinatology, and Child Health

Cite this

Lung to head ratio in infants with congenital diaphragmatic hernia does not predict long term pulmonary hypertension. / Garcia, Alejandro V.; Fingeret, Abbey L; Thirumoorthi, Arul S.; Hahn, Eunice; Leskowitz, Matthew J.; Aspelund, Gudrun; Krishnan, Usha S.; Stolar, Charles J.H.

In: Journal of Pediatric Surgery, Vol. 48, No. 1, 01.01.2013, p. 154-157.

Research output: Contribution to journalArticle

Garcia, Alejandro V. ; Fingeret, Abbey L ; Thirumoorthi, Arul S. ; Hahn, Eunice ; Leskowitz, Matthew J. ; Aspelund, Gudrun ; Krishnan, Usha S. ; Stolar, Charles J.H. / Lung to head ratio in infants with congenital diaphragmatic hernia does not predict long term pulmonary hypertension. In: Journal of Pediatric Surgery. 2013 ; Vol. 48, No. 1. pp. 154-157.
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abstract = "Purpose: Lung-to-head ratio (LHR) has been used for antenatal evaluation of infants with congenital diaphragmatic hernia (CDH). We hypothesized that LHR was predictive of acute and chronic pulmonary hypertension in infants with CDH. Methods: Echocardiograms on all inborn infants with CDH (December 2001-March 2011) were reviewed. Echocardiograms at 1 and 3 months post-repair and most recent follow-up were assessed for presence of pulmonary hypertension (PAH). LHR, gestational age, birth weight, extracorporeal membrane oxygenation (ECMO), and death rate were obtained. Bivariate and multivariate analyses were performed. Results: 106 infants with CDH had LHR obtained at median 28 weeks gestation (median LHR = 1.25 [range 0.4-5.3]). Median follow-up was 26.6 months (range 4.6-97.5). The long-term incidence of pulmonary hypertension was 16{\%}. LHR was significantly associated with pulmonary hypertension at one month (p = 0.0001) but not at 3 months (p = 0.22) or long-term (p = 0.54). LHR was predictive of ECMO use (p = 0.01) and death (p = 0.001). Conclusions: The overall incidence of PAH in infants with CDH decreases over time. Prenatal LHR predicts PAH at one month but not long-term in infants with CDH. The ability for LHR to predict PAH at one month but not long term may suggest remodeling of the pulmonary vasculature over time.",
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T1 - Lung to head ratio in infants with congenital diaphragmatic hernia does not predict long term pulmonary hypertension

AU - Garcia, Alejandro V.

AU - Fingeret, Abbey L

AU - Thirumoorthi, Arul S.

AU - Hahn, Eunice

AU - Leskowitz, Matthew J.

AU - Aspelund, Gudrun

AU - Krishnan, Usha S.

AU - Stolar, Charles J.H.

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Y1 - 2013/1/1

N2 - Purpose: Lung-to-head ratio (LHR) has been used for antenatal evaluation of infants with congenital diaphragmatic hernia (CDH). We hypothesized that LHR was predictive of acute and chronic pulmonary hypertension in infants with CDH. Methods: Echocardiograms on all inborn infants with CDH (December 2001-March 2011) were reviewed. Echocardiograms at 1 and 3 months post-repair and most recent follow-up were assessed for presence of pulmonary hypertension (PAH). LHR, gestational age, birth weight, extracorporeal membrane oxygenation (ECMO), and death rate were obtained. Bivariate and multivariate analyses were performed. Results: 106 infants with CDH had LHR obtained at median 28 weeks gestation (median LHR = 1.25 [range 0.4-5.3]). Median follow-up was 26.6 months (range 4.6-97.5). The long-term incidence of pulmonary hypertension was 16%. LHR was significantly associated with pulmonary hypertension at one month (p = 0.0001) but not at 3 months (p = 0.22) or long-term (p = 0.54). LHR was predictive of ECMO use (p = 0.01) and death (p = 0.001). Conclusions: The overall incidence of PAH in infants with CDH decreases over time. Prenatal LHR predicts PAH at one month but not long-term in infants with CDH. The ability for LHR to predict PAH at one month but not long term may suggest remodeling of the pulmonary vasculature over time.

AB - Purpose: Lung-to-head ratio (LHR) has been used for antenatal evaluation of infants with congenital diaphragmatic hernia (CDH). We hypothesized that LHR was predictive of acute and chronic pulmonary hypertension in infants with CDH. Methods: Echocardiograms on all inborn infants with CDH (December 2001-March 2011) were reviewed. Echocardiograms at 1 and 3 months post-repair and most recent follow-up were assessed for presence of pulmonary hypertension (PAH). LHR, gestational age, birth weight, extracorporeal membrane oxygenation (ECMO), and death rate were obtained. Bivariate and multivariate analyses were performed. Results: 106 infants with CDH had LHR obtained at median 28 weeks gestation (median LHR = 1.25 [range 0.4-5.3]). Median follow-up was 26.6 months (range 4.6-97.5). The long-term incidence of pulmonary hypertension was 16%. LHR was significantly associated with pulmonary hypertension at one month (p = 0.0001) but not at 3 months (p = 0.22) or long-term (p = 0.54). LHR was predictive of ECMO use (p = 0.01) and death (p = 0.001). Conclusions: The overall incidence of PAH in infants with CDH decreases over time. Prenatal LHR predicts PAH at one month but not long-term in infants with CDH. The ability for LHR to predict PAH at one month but not long term may suggest remodeling of the pulmonary vasculature over time.

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KW - ECMO

KW - Lung-to-head ratio

KW - Pulmonary hypertension

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