Abstract

The incidence of lung cancer in females is increasing, in contrast to that seen in males. In addition, the proportion of lung cancer cases in women attributable to smoking is approximately half of that seen in males. Female sex hormones, especially estrogen, may play a key role in this. Estrogen receptors ERα and ER have been detected on lung cancer cells and there is new evidence suggesting that hormone-replacement therapy may increase both the incidence of, and mortality from, lung cancer in women. Laboratory evidence lends credence to the carcinogenic effects of estrogens in lung cancer. This article summarizes the current evidence on their role in lung cancer.

Original languageEnglish (US)
Pages (from-to)509-518
Number of pages10
JournalExpert Review of Respiratory Medicine
Volume4
Issue number4
DOIs
StatePublished - Aug 1 2010

Fingerprint

Lung Neoplasms
Estrogens
Incidence
Hormone Replacement Therapy
Gonadal Steroid Hormones
Estrogen Receptors
Smoking
Mortality

Keywords

  • estrogen
  • estrogen receptors
  • fulvestrant
  • hormone-replacement therapy
  • lung cancer
  • women

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Immunology and Allergy
  • Public Health, Environmental and Occupational Health

Cite this

Lung cancer in women : Role of estrogens. / Chakraborty, Subhankar; Ganti, Apar Kishor P; Marr, Alissa S; Batra, Surinder Kumar.

In: Expert Review of Respiratory Medicine, Vol. 4, No. 4, 01.08.2010, p. 509-518.

Research output: Contribution to journalReview article

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