Lower omega-3 fatty acids are associated with the presence of anti-cyclic citrullinated peptide autoantibodies in a population at risk for future rheumatoid arthritis: A nested case-control study

Ryan W. Gan, Kendra A. Young, Gary O. Zerbe, M. Kristen Demoruelle, Michael H. Weisman, Jane H. Buckner, Peter K. Gregersen, Ted R Mikuls, James Robert O'Dell, Richard M. Keating, Michael J. Clare-Salzler, Kevin D. Deane, V. Michael Holers, Jill M. Norris

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Objective. The aim of this study was to investigate omega-3 fatty acid (FA) supplement use and omega-3 FAs in erythrocyte membranes [omega-3 FA % in erythrocyte membranes (RBC)] and their association with anti-CCP autoantibodies in a population without RA, but who are at genetic risk for RA. Methods. The multicentre Studies of the Etiology of RA (SERA) cohort includes RA-free subjects who are first-degree relatives of RA probands or are enriched with the HLA-DR4 allele. In a nested case-control study, 30 SERA cases were identified who were anti-CCP2 antibody positive. We further identified 47 autoantibody negative controls, frequency matched to cases on age at study visit, sex, race and study site. Anti-CCP2 status, self-reported omega-3 FA supplement use and omega-3 FA % in RBCs were obtained from a single visit. Results. Anti-CCP2 positive cases were less likely than controls to report omega-3 FA supplement use (odds ratio: 0.14; 95% CI 0.03, 0.68). In addition, the likelihood of anti-CCP2 positivity was inversely associated with total omega-3 FA % in RBCs (odds ratio: 0.47; 95% CI 0.24, 0.92, for a S.D. increase). Conclusion. The inverse association between anti-CCP2 positivity and self-reported omega-3 FA supplement use and omega-3 FA % in RBCs suggests that omega-3 FAs may protect against the development of RA-related autoimmunity in pre-clinical RA.

Original languageEnglish (US)
Pages (from-to)367-376
Number of pages10
JournalRheumatology (United Kingdom)
Volume55
Issue number2
DOIs
StatePublished - Oct 5 2015

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Omega-3 Fatty Acids
Autoantibodies
Case-Control Studies
Rheumatoid Arthritis
Erythrocyte Membrane
Odds Ratio
HLA-DR4 Antigen
cyclic citrullinated peptide
Autoimmunity
Multicenter Studies
Anti-Idiotypic Antibodies
Alleles
Population

Keywords

  • Autoantibodies
  • Epidemiology
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Rheumatology
  • Pharmacology (medical)

Cite this

Lower omega-3 fatty acids are associated with the presence of anti-cyclic citrullinated peptide autoantibodies in a population at risk for future rheumatoid arthritis : A nested case-control study. / Gan, Ryan W.; Young, Kendra A.; Zerbe, Gary O.; Kristen Demoruelle, M.; Weisman, Michael H.; Buckner, Jane H.; Gregersen, Peter K.; Mikuls, Ted R; O'Dell, James Robert; Keating, Richard M.; Clare-Salzler, Michael J.; Deane, Kevin D.; Michael Holers, V.; Norris, Jill M.

In: Rheumatology (United Kingdom), Vol. 55, No. 2, 05.10.2015, p. 367-376.

Research output: Contribution to journalArticle

Gan, RW, Young, KA, Zerbe, GO, Kristen Demoruelle, M, Weisman, MH, Buckner, JH, Gregersen, PK, Mikuls, TR, O'Dell, JR, Keating, RM, Clare-Salzler, MJ, Deane, KD, Michael Holers, V & Norris, JM 2015, 'Lower omega-3 fatty acids are associated with the presence of anti-cyclic citrullinated peptide autoantibodies in a population at risk for future rheumatoid arthritis: A nested case-control study', Rheumatology (United Kingdom), vol. 55, no. 2, pp. 367-376. https://doi.org/10.1093/rheumatology/kev266
Gan, Ryan W. ; Young, Kendra A. ; Zerbe, Gary O. ; Kristen Demoruelle, M. ; Weisman, Michael H. ; Buckner, Jane H. ; Gregersen, Peter K. ; Mikuls, Ted R ; O'Dell, James Robert ; Keating, Richard M. ; Clare-Salzler, Michael J. ; Deane, Kevin D. ; Michael Holers, V. ; Norris, Jill M. / Lower omega-3 fatty acids are associated with the presence of anti-cyclic citrullinated peptide autoantibodies in a population at risk for future rheumatoid arthritis : A nested case-control study. In: Rheumatology (United Kingdom). 2015 ; Vol. 55, No. 2. pp. 367-376.
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title = "Lower omega-3 fatty acids are associated with the presence of anti-cyclic citrullinated peptide autoantibodies in a population at risk for future rheumatoid arthritis: A nested case-control study",
abstract = "Objective. The aim of this study was to investigate omega-3 fatty acid (FA) supplement use and omega-3 FAs in erythrocyte membranes [omega-3 FA {\%} in erythrocyte membranes (RBC)] and their association with anti-CCP autoantibodies in a population without RA, but who are at genetic risk for RA. Methods. The multicentre Studies of the Etiology of RA (SERA) cohort includes RA-free subjects who are first-degree relatives of RA probands or are enriched with the HLA-DR4 allele. In a nested case-control study, 30 SERA cases were identified who were anti-CCP2 antibody positive. We further identified 47 autoantibody negative controls, frequency matched to cases on age at study visit, sex, race and study site. Anti-CCP2 status, self-reported omega-3 FA supplement use and omega-3 FA {\%} in RBCs were obtained from a single visit. Results. Anti-CCP2 positive cases were less likely than controls to report omega-3 FA supplement use (odds ratio: 0.14; 95{\%} CI 0.03, 0.68). In addition, the likelihood of anti-CCP2 positivity was inversely associated with total omega-3 FA {\%} in RBCs (odds ratio: 0.47; 95{\%} CI 0.24, 0.92, for a S.D. increase). Conclusion. The inverse association between anti-CCP2 positivity and self-reported omega-3 FA supplement use and omega-3 FA {\%} in RBCs suggests that omega-3 FAs may protect against the development of RA-related autoimmunity in pre-clinical RA.",
keywords = "Autoantibodies, Epidemiology, Rheumatoid arthritis",
author = "Gan, {Ryan W.} and Young, {Kendra A.} and Zerbe, {Gary O.} and {Kristen Demoruelle}, M. and Weisman, {Michael H.} and Buckner, {Jane H.} and Gregersen, {Peter K.} and Mikuls, {Ted R} and O'Dell, {James Robert} and Keating, {Richard M.} and Clare-Salzler, {Michael J.} and Deane, {Kevin D.} and {Michael Holers}, V. and Norris, {Jill M.}",
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T1 - Lower omega-3 fatty acids are associated with the presence of anti-cyclic citrullinated peptide autoantibodies in a population at risk for future rheumatoid arthritis

T2 - A nested case-control study

AU - Gan, Ryan W.

AU - Young, Kendra A.

AU - Zerbe, Gary O.

AU - Kristen Demoruelle, M.

AU - Weisman, Michael H.

AU - Buckner, Jane H.

AU - Gregersen, Peter K.

AU - Mikuls, Ted R

AU - O'Dell, James Robert

AU - Keating, Richard M.

AU - Clare-Salzler, Michael J.

AU - Deane, Kevin D.

AU - Michael Holers, V.

AU - Norris, Jill M.

PY - 2015/10/5

Y1 - 2015/10/5

N2 - Objective. The aim of this study was to investigate omega-3 fatty acid (FA) supplement use and omega-3 FAs in erythrocyte membranes [omega-3 FA % in erythrocyte membranes (RBC)] and their association with anti-CCP autoantibodies in a population without RA, but who are at genetic risk for RA. Methods. The multicentre Studies of the Etiology of RA (SERA) cohort includes RA-free subjects who are first-degree relatives of RA probands or are enriched with the HLA-DR4 allele. In a nested case-control study, 30 SERA cases were identified who were anti-CCP2 antibody positive. We further identified 47 autoantibody negative controls, frequency matched to cases on age at study visit, sex, race and study site. Anti-CCP2 status, self-reported omega-3 FA supplement use and omega-3 FA % in RBCs were obtained from a single visit. Results. Anti-CCP2 positive cases were less likely than controls to report omega-3 FA supplement use (odds ratio: 0.14; 95% CI 0.03, 0.68). In addition, the likelihood of anti-CCP2 positivity was inversely associated with total omega-3 FA % in RBCs (odds ratio: 0.47; 95% CI 0.24, 0.92, for a S.D. increase). Conclusion. The inverse association between anti-CCP2 positivity and self-reported omega-3 FA supplement use and omega-3 FA % in RBCs suggests that omega-3 FAs may protect against the development of RA-related autoimmunity in pre-clinical RA.

AB - Objective. The aim of this study was to investigate omega-3 fatty acid (FA) supplement use and omega-3 FAs in erythrocyte membranes [omega-3 FA % in erythrocyte membranes (RBC)] and their association with anti-CCP autoantibodies in a population without RA, but who are at genetic risk for RA. Methods. The multicentre Studies of the Etiology of RA (SERA) cohort includes RA-free subjects who are first-degree relatives of RA probands or are enriched with the HLA-DR4 allele. In a nested case-control study, 30 SERA cases were identified who were anti-CCP2 antibody positive. We further identified 47 autoantibody negative controls, frequency matched to cases on age at study visit, sex, race and study site. Anti-CCP2 status, self-reported omega-3 FA supplement use and omega-3 FA % in RBCs were obtained from a single visit. Results. Anti-CCP2 positive cases were less likely than controls to report omega-3 FA supplement use (odds ratio: 0.14; 95% CI 0.03, 0.68). In addition, the likelihood of anti-CCP2 positivity was inversely associated with total omega-3 FA % in RBCs (odds ratio: 0.47; 95% CI 0.24, 0.92, for a S.D. increase). Conclusion. The inverse association between anti-CCP2 positivity and self-reported omega-3 FA supplement use and omega-3 FA % in RBCs suggests that omega-3 FAs may protect against the development of RA-related autoimmunity in pre-clinical RA.

KW - Autoantibodies

KW - Epidemiology

KW - Rheumatoid arthritis

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